000			03724nam a22003615i 4500
001			233918
003			ES-VaUE
005			20221220020530.0
007			cr nn 008mamaa
008			101029s2011 xxu| s |||| 0|eng d
020			_a9781607619314
024	7		_a10.1007/978-1-60761-931-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aChemical Library Design _cedited by Joe Zhongxiang Zhou.
250			_a1st edition 2011
264		1	_aTotowa, NJ _bHumana Press _c2011
300			_a1 recurso en línea (X, 340 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v685
505	0		_aHistorical Overview of Chemical Library Design -- Chemoinformatics and Library Design -- Molecular Library Design Using Multi-Objective Optimization Methods -- A Scalable Approach to Combinatorial Library Design -- Application of Free-Wilson Selectivity Analysis for Combinatorial Library Design -- Application of QSAR and Shape Pharmacophore Modeling Approaches for Targeted Chemical Library Design -- Combinatorial Library Design from Reagent Pharmacophore Fingerprints -- Docking Methods for Structure-Based Library Design -- Structure-Based Library Design in Efficient Discovery of Novel Inhibitors -- Structure-Based and Property-Compliant Library Design of 11-HSD1 Adamantyl Amide Inhibitors -- Design of Screening Collections for Successful Fragment-Based Lead Discovery -- Fragment-Based Drug Design -- LEAP into the Pfizer Global Virtual Library (PGVL) Space: Creation of Readily Synthesizable Design Ideas Automatically -- The Design, Annotation, and Application of a Kinase-Targeted-Library -- PGVL Hub: An Integrated Desktop Tool for Medicinal Chemists to Streamline Design and Synthesis of Chemical Libraries and Singleton Compounds -- Design of Targeted Libraries Against the Human Chk1 Kinase Using PGVL Hub -- GLARE: A Tool for Product-Oriented Design of Combinatorial Libraries -- CLEVER: A General Design Tool for Combinatorial Libraries.
520			_aChemical library technologies have brought about dramatic changes in the drug discovery process, and, though still evolving, they have become an integral part of ongoing drug discovery research. In Chemical Library Design, experts in the field provide methods and detailed protocols delving into this key process of selecting useful, biologically relevant compounds from large pools of synthesizable candidates. This compendium includes chapters on historical overviews, state-of-the-art methodologies, including structure-based and fragment-based library design, practical software tools, and successful and important applications of chemical library design. As a volume in the popular Methods in Molecular Biology™ series, the thorough contributions provide the kind of meticulous description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Chemical Library Design is an ideal reference for all scientists seeking the technology needed to aid in the search for new and vital drugs.
700	1		_aZhou, Joe Zhongxiang _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607619307
776	0	8	_iPrinted edition: _z9781607619321
776	0	8	_iPrinted edition: _z9781493961542
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-931-4 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2011
999			_c233918 _d233918