000			04465nam a22003615i 4500
001			233930
003			ES-VaUE
005			20221220020531.0
007			cr nn 008mamaa
008			180321s2018 xxu| s |||| 0|eng d
020			_a9781493977802
024	7		_a10.1007/978-1-4939-7780-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aChromothripsis _bMethods and Protocols _cedited by Franck Pellestor.
250			_a1st edition 2018
264		1	_aNew York, NY _bSpringer International Publishing _c2018
300			_a1 recurso en línea (XI, 367 páginas) _b85 ilustraciones, 73 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v1769
505	0		_aThe Genomic Characteristics and Origin of Chromothripsis -- Clinical Consequences of Chromothripsis and Other Catastrophic Cellular Events -- Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo -- Chromothripsis and the Macroevolution Theory -- Analysis of Chromothripsis by Combined FISH and Microarray Analysis -- Chromothripsis Detectable in Small Supernumerary Marker Chromosomes (sSMC) Using Fluorescence In Situ Hybridization (FISH) -- Identification of Chromothripsis in Biopsy Using SNP-Based Microarray -- Detection of Chromothripsis in Plants -- RNA-Seq Analysis to Detect Abnormal Fusion Transcripts Linked to Chromothripsis -- Experimental Determination of Checkpoint Adaptation by Mitotic Shake-Off and Microscopy -- A Role for Retrotransposons in Chromothripsis -- Generation of Micronuclei and Detection of Chromosome Pulverization -- Detection of Impaired DNA Replication and Repair in Micronuclei as Indicators of Genomic Instability and Chromothripsis -- Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability -- Genes, Proteins, and Biological Pathways Preventing Chromothripsis -- Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability -- Chromothripsis Detection and Characterization Using the CTLPScanner Web Server -- ChromothripsisDB: A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data -- Time-Lapse Imaging for the Detection of Chromosomal Abnormalities in Primate Pre-Implantation Embryos -- Correlative Live Imaging and Immunofluorescence for Analysis of Chromosome Segregation in Mouse Preimplantation Embryos -- Experimental Induction of Genome Chaos -- Looking for Broken TAD Boundaries and Changes on DNA Interactions: Clinical Guide to 3D Chromatin Changes Analysis in Complex Chromosomal Rearrangements and Chromothripsis.
520			_aThis detailed book presents an up-to-date view on methods and experimental approaches developed to identify and explore the chromothripsis phenomenon. Beginning with a section exploring the genesis and impact of chromothripsis, the collection continues by covering the identification of chromothripsis, the causal mechanisms of chromothripsis, the bioinformatics tools for chromothripsis analysis, and experimental systems recently developed for the in vitro investigation of chromothripsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.  Authoritative and practical, Chromothripsis: Methods and Protocols serves as a vital resource for cell biologists, molecular biologists, cytogeneticists, and geneticists investigating chromothripsis, but also for students and researchers new to the field of chromothripsis and genomic instability.
700	1		_aPellestor, Franck _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493977796
776	0	8	_iPrinted edition: _z9781493977819
776	0	8	_iPrinted edition: _z9781493992836
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-7780-2 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2018
999			_c233930 _d233930