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008			170405s2017 xxu| s |||| 0|eng d
020			_a9781493969180
024	7		_a10.1007/978-1-4939-6918-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aMetals in the Brain _bMeasurement and Imaging _cedited by Anthony R. White.
250			_a1st edition 2017
264		1	_aNew York, NY _bSpringer International Publishing _c2017
300			_a1 recurso en línea (XII, 270 páginas) _b58 ilustraciones, 31 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v124
505	0		_aIntroduction and Overview -- X-Ray Microscopy for Detection of Metals in the Brain -- Imaging Metals in the Brain by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry -- Fluorescent Probes for the Analysis of Labile Metals in the Brain Cells -- Probing Biological Trace Metals with Fluorescent Indicators -- Microdissection of Brain Tissue to Resolve the Comparative Dissemination of Metal Concentrations in Neurodegenerative Diseases, Focusing on Manganese -- Analysis of Trace Elements and Metalloproteins in Fractionated Human Brain Samples using Size Exclusion Inductively Couples Mass Spectrometry -- Size-Fractionation of Metal Species from Serum Samples for Studying Element Biodistribution in Alzheimer's Disease -- Lead Uptake and Localization in Glial Cell Cultures -- Evaluating Iron Flux in the Brain -- Current Methods used to Probe and Quantify Intracellular Total and Free Zn(II) Dynamics, and Subcellular Distribution in Cultured Neurons -- Monitoring Intracellular Zn2+ using Fluorescent Sensors: Facts and Artifacts -- Measuring Changes in Brain Manganese or Iron using Magnetic Resonance Imaging (MRI) -- Treatment and Measurement of Metals in Brain Cell Cultures.
520			_aThis volume explores methods used to examine metal levels and distribution in brain tissue or brain-derived cells. The chapters in this book discuss the use of fluorescent metal probes, synchrotron-based X-ray microscopy, ICP-MS, laser ablation-ICP-MS, laser-based tissue microdissection, MRI image analysis, fractionation of cell tissue samples for metal analysis, and metal treatment of cells. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Practical and cutting-edge, Metals in the Brain: Measurement and Imaging is a valuable resource for researchers in the rapidly growing area of neuroscience research.
700	1		_aWhite, Anthony R _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493969166
776	0	8	_iPrinted edition: _z9781493969173
776	0	8	_iPrinted edition: _z9781493983384
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-6918-0 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2017
999			_c233958 _d233958