000			03474nam a22003615i 4500
001			234060
003			ES-VaUE
005			20221220020538.0
007			cr nn 008mamaa
008			100301s2009 xxu| s |||| 0|eng d
020			_a9781603272636
024	7		_a10.1007/978-1-60327-263-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aAnimal Models of Epilepsy _bMethods and Innovations _cedited by Scott C. Baraban.
250			_a1st edition 2009
264		1	_aTotowa, NJ _bHumana Press _c2009
300			_a1 recurso en línea (X, 265 páginas) _b65 ilustraciones, 7 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v40
505	0		_aThe Nematode, Caenorhabditis elegans, as an Emerging Model for Investigating Epilepsy -- The Genetics and Molecular Biology of Seizure Susceptibility in Drosophila -- The Albino Xenopus laevis Tadpole as a Novel Model of Developmental Seizures -- Zebrafish as a Simple Vertebrate Organism for Epilepsy Research -- Modeling Tuberous Sclerosis Complex: Brain Development and Hyperexcitability -- BK Potassium Channel Mutations Affecting Neuronal Function and Epilepsy -- Mouse Models of Benign Familial Neonatal Convulsions (BFNC): Mutations in KCNQ (Kv7) Genes -- Interneuron Loss as a Cause of Seizures: Lessons from Interneuron-Deficient Mice -- Imaging Seizure Propagation In Vitro -- Complexity Untangled: Large-Scale Realistic Computational Models in Epilepsy -- Organotypic Hippocampal Slice Cultures as a Model of Limbic Epileptogenesis -- Seizure Analysis and Detection In Vivo -- Viral Vector Gene Therapy for Epilepsy -- Neural Stem Cells in Experimental Mesial Temporal Lobe Epilepsy.
520			_aWith its complex anatomical, molecular, electrophysiological and behavioral components, epilepsy provides the neuroscientist with nearly boundless opportunities to examine basic neurobiological mechanisms. In Animal Models of Epilepsy: Methods and Innovations, prominent investigators in the field examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species such as Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). While covering some traditional models, the volume also explores the newest innovations like modeling seizure activity in silica and advanced strategies for seizure detection and gene therapy. As a volume in the successful Neuromethods™ series, the chapters provide clear, step-by-step protocols and thought-provoking reviews of the most recent advancements in the field. Comprehensive and cutting-edge, Animal Models of Epilepsy: Methods and Innovations is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.
700	1		_aBaraban, Scott C _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607611257
776	0	8	_iPrinted edition: _z9781603272629
776	0	8	_iPrinted edition: _z9781493961146
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60327-263-6 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2009
999			_c234060 _d234060