000			04687nam a22003735i 4500
001			234181
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007			cr nn 008mamaa
008			150130s2015 xxu| s |||| 0|eng d
020			_a9781493922970
024	7		_a10.1007/978-1-4939-2297-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aMouse Models of Cancer _bMethods and Protocols _cedited by Robert Eferl, Emilio Casanova.
250			_a1st edition 2015
264		1	_aNew York, NY _bSpringer International Publishing _c2015
300			_a1 recurso en línea (XI, 463 páginas) _b96 ilustraciones, 87 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v1267
505	0		_aModeling Cancer Using Genetically Engineered Mice -- Lung Adenocarcinomas: Comparison Between Mice and Men -- Mouse Models of Breast Cancer -- Genetically Engineered Mouse Models to Study Prostate Cancer -- Practical Use of Advanced Mouse Models for Lung Cancer -- Generation and Analysis of Mouse Intestinal Tumors and Organoids Harboring APC and K-Ras Mutations -- Induction of Colorectal Cancer in Mice and Histomorphometric Evaluation of Tumors -- Mouse Models of Liver Cancer -- Current Methods in Mouse Models of Pancreatic Cancer -- Mouse Models of Non-Melanoma Skin Cancer -- Clinicopathological Characterization of Mouse Models of Melanoma -- Modeling BCR/ABL Driven Malignancies in the Mouse -- Methods to Generate Genetically-Engineered Mouse Models of Soft-Tissue Sarcoma -- Characterization of Mouse Model-derived Osteosarcoma (OS) Cells in vitro and in vivo -- Genetically Engineered Mouse and Orthotopic Human Tumor Xenograft Models of Retinoblastoma -- Tumor Imaging Technologies in Mouse Models -- Tumor Angiogenesis: Methods to Analyze Tumor Vasculature and Vessel Normalization in Mouse Models of Cancers -- Transplantable Mouse Tumor Models of Breast Cancer Metastasis -- Methods to Study Tumor Cells and Residual Tumor Cells in Mouse Models of Oncogene Dependence -- Generation of Transgenic Mouse Model Using PTTG as an Oncogene -- Modeling the Study of DNA Damage Responses in Mice -- Methods to Study Tumor Surveillance Using Tumor Cell Transplantation into Genetically Engineered Mice.
520			_aThis volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research. Recent genome studies, together with refined genetic engineering techniques, have greatly increased the value of using mice for research on cancer and other human disorders. The chapters of this book will support scientists in choosing the most suitable mouse models for their research questions. The book provides detailed methodological information for genetic or chemical induction of different types of cancer, histomorphometric cancer analysis, and in vivo imaging, as well as protocols to investigate oncogene addiction, immune surveillance, and hallmarks of cancer such as angiogenesis or metastasis. Four review-like articles provide background information on mouse technologies and histopathologic differences between mouse and human cancers. The mouse models described in individual chapters will fuel the understanding of cancer initiation, immune system roles, tumor angiogenesis, invasion, metastasis, and the relevance of molecular diversity observed among human cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and resourceful, Mouse Models of Cancers: Methods and Protocols, is a valuable laboratory resource for all researchers, from the graduate level upwards, who study cancer and new possibilities for its treatment.
700	1		_aEferl, Robert _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aCasanova, Emilio _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493922963
776	0	8	_iPrinted edition: _z9781493922987
776	0	8	_iPrinted edition: _z9781493948444
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-2297-0 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2015
999			_c234181 _d234181