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008			100715s2010 xxu| s |||| 0|eng d
020			_a9781607610588
024	7		_a10.1007/978-1-60761-058-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aMouse Models for Drug Discovery _bMethods and Protocols _cedited by Gabriele Proetzel, Michael V. Wiles.
250			_a1st edition 2010
264		1	_aTotowa, NJ _bHumana Press _c2010
300			_a1 recurso en línea (XII, 421 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v602
505	0		_aImproving Toxicity Screening and Drug Development by Using Genetically Defined Strains -- The Sophisticated Mouse: Protecting a Precious Reagent -- Genetically Engineered Mouse Models in Drug Discovery Research -- Engineering the Mouse Genome to Model Human Disease for Drug Discovery -- Profiling of Drug Action Using Reporter Mice and Molecular Imaging -- Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies -- Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease -- Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans -- Mouse Models of Type II Diabetes Mellitus in Drug Discovery -- Cholesterol Absorption and Metabolism -- Collagen-Induced Arthritis in Mice -- Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening -- Models of Metastasis in Drug Discovery -- Methods for Evaluating Effects of an Irinotecan + 5-Fluorouracil/Leucovorin (IFL) Regimen in an Orthotopic Metastatic Colorectal Cancer Model Utilizing In Vivo Bioluminescence Imaging -- CML Mouse Model in Translational Research -- Mouse Models for Studying Depression-Like States and Antidepressant Drugs -- Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors -- Experimental Models of Anxiety for Drug Discovery and Brain Research -- Mouse Models of Neurodegenerative Diseases: Criteria and General Methodology -- Neuromuscular Disease Models and Analysis -- Murine Model of Cutaneous Infection with Streptococcus pyogenes -- Murine Model of Pneumococcal Pneumonia -- Murine Model of Polymicrobial Septic Peritonitis Using Cecal Ligation and Puncture (CLP) -- Erratum to: Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies.
520			_aAs the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.
700	1		_aProetzel, Gabriele _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aWiles, Michael V _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607610670
776	0	8	_iPrinted edition: _z9781607610571
776	0	8	_iPrinted edition: _z9781493961214
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-058-8 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2010
999			_c234307 _d234307