000			03246nam a22003615i 4500
001			234308
003			ES-VaUE
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007			cr nn 008mamaa
008			100301s1980 xxu| s |||| 0|eng d
020			_a9781603274036
024	7		_a10.1007/978-1-60327-403-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
100	1		_aCosta, Max. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	1	0	_aMetal Carcinogenesis Testing _bPrinciples and In Vitro Methods _cby Max Costa.
250			_a1st edition 1980
264		1	_aTotowa, NJ _bHumana Press _c1980
300			_a1 recurso en línea (XIII, 169 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aBiological Methods
505	0		_aMetal-Induced Cancer in Humans and Experimental Animals -- Epidemiological Studies and Occupational Exposures -- Metal Carcinogenesis In Experimental Animals -- Exposure to Metal Carcinogens In The General Population -- Mechanisms of Metal Carcinogenesis -- Molecular Mechanisms of Metal Carcinogenesis in Experimental Animals -- In Vitro and Cell Culture Analysis of Metal Carcinogenesis -- Principles and Methods of In Vitro Metal Carcinogensis Testing -- Principles of In Vitro Metal Carcinogenesis -- Methods for In Vitro Metal Carcinogenesis Testing -- Principles and Methods of Industrial Metal Carcinogenesis Testing.
520			_aMetal Carcinogenesis Testing explains fundamental principles of metal carcinogenesis as they are currently understood, and provides detailed practical descriptions of rapid and inexpensive in vitro assay methodology presently in use for the detection of potentially carci­ nogenic metals and their compounds. Mounting experimental evidence has suggested that a number of metals and their compounds are potentially carcinogenic to humans. Since humans are exposed to these potentially carcinogenic metals in industrial situations and through environmental pollution, it is essential that experimental protocols be available to identify the specific metal compounds that are potentially carcinogenic. This book affords a thorough description of the various carcinogenesis test systems available for metals, centering on those that are rapid, inexpensive, and most reliable. The principles are discussed at the level of human exposure, of animal studies, and of research in vitro. Additionally, the molecular mechanisms of metal-induced cancer are considered at each ofthese three levels.In large part, the emphasis rests on the use of in vitro, biochemical and bacterial studies, including tissue culture, because these methods are the basis of the rapid and inexpensive screening of potentially carcinogenic substances.
776	0	8	_iPrinted edition: _z9781489940919
776	0	8	_iPrinted edition: _z9780896030176
776	0	8	_iPrinted edition: _z9781489940902
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60327-403-6 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_1980
999			_c234308 _d234308