000			03686nam a22003735i 4500
001			234432
003			ES-VaUE
005			20221220020602.0
007			cr nn 008mamaa
008			100301s1996 xxu| s |||| 0|eng d
020			_a9781592595877
024	7		_a10.1385/0896033422 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aPrion Diseases _cedited by Harry F. Baker, Rosalind M. Ridley.
250			_a1st edition 1996
264		1	_aTotowa, NJ _bHumana Press _c1996
300			_a1 recurso en línea (XV, 319 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Medicine _x1940-6037 _v3
505	0		_aThe Paradox of Prion Disease -- Human Spongiform Encephalopathy -- Neuropathological Diagnosis of Human Prion Disease -- Neuropathological Diagnosis of Human Prion Disease -- The Diagnosis of Bovine Spongiform Encephalopathy and Scrapie by the Detection of Fibrils and the Abnormal Protein lsoform -- Exposure to, and Inactivation of, the Unconventional Agents that Cause Transmissible Degenerative Encephalopathies -- Surveillance of Prion Diseases in Humans -- Environmental Causes of Human Spongiform Encephalopathy -- Bovine Spongiform Encephalopathy -- Handling the BSE Epidemic in Great Britain -- Special Problems of Genetic Counseling in Adult-Onset Diseases -- Genotyping and Susceptibility of Sheep to Scrapie -- Strain Typing Studies of Scrapie and BSE -- PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies -- Transgenic Approaches to Prion "Species-Barrier" Effects -- Methods for Studying Prion Protein Amyloid -- Methods for Studying Prion Protein (PrP) Metabolism and the Formation of Protease-Resistant PrP in Cell Culture and Cell-Free Systems -- Immunohistochemistry of Resinated Tissues for Light and Electron Microscopy.
520			_aIn Prion Diseases leading researchers and clinicians describe their state-of-the-art findings and hypotheses arising from a variety of different approaches to this group of diseases. Their approaches include clinical presentations, epidemiology, transgenic methods, and diagnostic tests via transmission electron microscopy and immunoblotting. The diseases covered include human and animal spongiform encephalopathies, such as Creutzfeldt-Jakob disease, mad cow disease, and scrapie. Prion Diseases illuminates the conflicting hypotheses that have evolved to explain these diverse disorders which can appear as infectious diseases a genetically determined diseases, as well as ones sharing neuropathological similarities with such common neurodegenerative diseases as Alzheimer's disease, Parkinson's disease, and amyotropic lateral sclerosis. It provides a much-needed overview of various approaches to understanding these diseases by showing how researchers have analyzed their different facets, ranging from the epidemiology of the human versions to molecular genetics of the animal forms of the diseases.
700	1		_aBaker, Harry F _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aRidley, Rosalind M _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781489940407
776	0	8	_iPrinted edition: _z9780896033429
776	0	8	_iPrinted edition: _z9781489940391
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/0896033422 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_1996
999			_c234432 _d234432