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020 _a9781597454636
024 7 _a10.1007/978-1-59745-463-6
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
245 1 0 _aBiomarker Methods in Drug Discovery and Development
_cedited by Feng Wang.
250 _a1st edition 2008
264 1 _aTotowa, NJ
_bHumana Press
_c2008
300 _a1 recurso en línea (XVIII, 396 páginas)
_b88 ilustraciones, 9 ilustraciones a color
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aMethods in Pharmacology and Toxicology
_x1940-6053
505 0 _aBiomarker Sample Collection and Handling in the Clinical Setting to Support Early-Phase Drug Development -- Gene Expression-Based Biomarkers of Drug Safety -- Profiling Gene Expression Signatures Using Fluorescent Microspheres -- Real-Time Polymerase Chain Reaction Gene Expression Assays in Biomarker Discovery and Validation -- SAGE Analysis in Identifying Phenotype Single Nucleotide Polymorphisms -- Single Nucleotide Polymorphisms and DNA Methylation Analysis Using Pyrosequencing Methods -- The Application of Laser Capture Microdissection for the Analysis of Cell-Type-Specific Gene Expression in a Complex Tissue: -- The Use of Two-Dimensional Gel Electrophoresis for Plasma Biomarker Discovery -- Difference In-Gel Electrophoresis: A High-Resolution Protein Biomarker Research Tool -- Label-Free Mass Spectrometry-Based Protein Quantification Technologies in Protein Biomarker Discovery -- Top-Down Quantitative Proteomic Analysis Using a Highly Multiplexed Isobaric Mass Tagging Strategy -- SELDI Technology for Identification of Protein Biomarkers -- Sandwich ELISA Microarrays: Generating Reliable and Reproducible Assays for High-Throughput Screens -- LC-MS Metabonomics Methodology in Biomarker Discovery -- GC-MS-Based Metabolomics -- NMR-Based Metabolomics for Biomarker Discovery -- Unraveling Glycerophospholipidomes by Lipidomics.
520 _aWithin the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols which aim to apply multiple technologies at different molecular levels in order to surmount the monumental and complex task of transforming the pharmaceutical research and development processes. As a volume in the Methods in Pharmacology and Toxicology™ series, this book offers user-friendly, step-by-step laboratory protocols for readily reproducible experiments. Comprehensive and state-of-the-art, Biomarker Methods in Drug Discovery and Development is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.
700 1 _aWang, Feng
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 0 8 _iPrinted edition:
_z9781617379253
776 0 8 _iPrinted edition:
_z9781934115237
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-59745-463-6
_z(usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
988 _aSpringer_Protocols_2008
999 _c234462
_d234462