000			03259nam a22003615i 4500
001			234587
003			ES-VaUE
005			20221220020612.0
007			cr nn 008mamaa
008			170817s2017 xxu| s |||| 0|eng d
020			_a9781493972081
024	7		_a10.1007/978-1-4939-7208-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aDevelopmental and Reproductive Toxicology _cedited by Ali S. Faqi.
250			_a1st edition 2017
264		1	_aNew York, NY _bSpringer International Publishing _c2017
300			_a1 recurso en línea (XII, 314 páginas) _b24 ilustraciones, 17 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aMetabolism and Drug-Drug Interaction in Pregnant Mother/Placenta/Fetus -- Critical Periods of Development in Teratology -- Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo-Fetal Development, and Pre- and Postnatal Developmental Toxicology Studies -- A Developmental and Reproductive Toxicology Program for Chemical Registration -- The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility -- Effects of Chemicals on Mammary Gland Development -- Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals -- Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies -- High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays.
520			_aThis meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab.  Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resourc e for researchers working in this vital field of study.
700	1		_aFaqi, Ali S _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493972067
776	0	8	_iPrinted edition: _z9781493972074
776	0	8	_iPrinted edition: _z9781493984169
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-7208-1 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2017
999			_c234587 _d234587