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001			234684
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008			100301s2001 xxu| s |||| 0|eng d
020			_a9781592591343
024	7		_a10.1385/1592591345 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aMolecular Pathology of the Prions _cedited by Harry F. Baker.
250			_a1st edition 2001
264		1	_aTotowa, NJ _bHumana Press _c2001
300			_a1 recurso en línea (XII, 279 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Medicine _x1940-6037 _v59
505	0		_aWhat Would Thomas Henry Huxley Have Made of Prion Diseases? -- Prion Protein as Copper-Binding Protein at the Synapse -- A Function for the Prion Protein? -- Prion Protein Peptide -- Characterization of Bovine Spongiform Encephalopathy and Scrapie Strains/Isolates by Immunochemical Analysis of PrPSc -- Differential Targeting of Neurons by Prion Strains -- Transgenic Studies of Prion Diseases -- Prions: From Neurografts to Neuroinvasion -- Cellular and Transgenic Models of Familial Prion Diseases -- Central Nervous System Inflammation and Prion Disease Pathogenesis -- The Electroneuropathology of Prion Disease -- Transmissible Spongiform Encephalopathy Neurobiology and Ultrastructure Suggests Extracellular PrPSc Conversion Consistent with Classical Amyloidosis -- Conformation as Therapeutic Target in the Prionoses and Other Neurodegenerative Conditions -- Prions of Yeast From Cytoplasmic Genes to Heritable Amyloidosis.
520			_aIt is now widely agreed that the prion protein plays a key role in the molecular pathogenesis of prion diseases-diseases that involve the misfolding of proteins-in both humans and animals. In Molecular Pathology of the Prions, noted prion researcher Harry Baker has asked internationally recognized investigators to review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. Other topics addressed include the neuronal death that occurs in prion disease, the different strains of prion disease agents, and the accumulation of protein deposits within brain parenchyma. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, including research techniques now likely to enjoy broader application for the more common proteinopathies, such as Alzheimer's and Parkinson's diseases.
700	1		_aBaker, Harry F _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617372520
776	0	8	_iPrinted edition: _z9780896039247
776	0	8	_iPrinted edition: _z9781489942036
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592591345 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2001
999			_c234684 _d234684