000			03721nam a22003735i 4500
001			234835
003			ES-VaUE
005			20221220020627.0
007			cr nn 008mamaa
008			100715s2010 xxu| s |||| 0|eng d
020			_a9781607614746
024	7		_a10.1007/978-1-60761-474-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aTransgenic and Mutant Tools to Model Brain Disorders _cedited by Allan V. Kalueff, Carisa L. Bergner.
250			_a1st edition 2010
264		1	_aTotowa, NJ _bHumana Press _c2010
300			_a1 recurso en línea (XIV, 246 páginas) _b17 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v44
505	0		_aGeneral Approaches -- Mutant and Transgenic Zebrafish in Modeling Neurobehavioral Disorders -- Knockout and Mutant Rats -- Rat Mutants with Lateralized Rotational Behavior for Studying Disturbances in Cerebral Asymmetries and Their Involvement in Brain Disorders -- GABAA Receptor ?1 Subunit (Gabra1) Knockout Mice: Review and New Results -- Basal Ganglia Disorders in Genetic Models and Experimentally Induced Lesions -- Estrogen-Deficient Mouse Models in the Study of Brain Injury and Disease -- Specific Brain Disorders -- The Utility of Genetically Modified Animals in Modeling OCD-Spectrum Disorders -- Investigating Rett Syndrome Through Genetic Mouse Models: Presymptomatic, Clearly Symptomatic Phases, and Innovative Therapeutic Approaches -- Genetic Animal Models of Anxiety -- Genetic Animal Models of Depression -- Environmental Enrichment and Gene-Environment Interactions in Mouse Models of Brain Disorders -- Mutant and Transgenic Tools in Modeling Schizophrenia.
520			_aAs the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders. In Transgenic and Mutant Tools to Model Brain Disorders, leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research. Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia. As a volume in the successful Neuromethods™ series, the chapters provide authoritative reviews covering the most commonly used approaches in the field. Cutting-edge and concise, Transgenic and Mutant Tools to Model Brain Disorders offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.
700	1		_aKalueff, Allan V _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBergner, Carisa L _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607614845
776	0	8	_iPrinted edition: _z9781607614739
776	0	8	_iPrinted edition: _z9781493961450
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60761-474-6 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2010
999			_c234835 _d234835