000			03894nam a22003495i 4500
001			234900
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007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9781592598328
024	7		_a10.1385/1592598323 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aDrug Metabolism and Transport _bMolecular Methods and Mechanisms _cedited by Lawrence H. Lash.
250			_a1st edition 2005
264		1	_aTotowa, NJ _bHumana Press _c2005
300			_a1 recurso en línea (X, 388 páginas) _b110 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aRenal Cytochrome P450s and Flavin-Containing Monooxygenases -- Experimental Approaches for the Study of Cytochrome P450 Gene Regulation -- Insulin and Growth Factor Signaling -- Catalytic Function and Expression of Glutathione Transferase Zeta -- Glucuronidation of Fatty Acids and Prostaglandins by Human UDP-Glucuronosyltransferases -- Transcriptional Regulation of UDP-Glucuronosyltransferases -- Phenotypic and Genotypic Characterization of N-Acetylation -- Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen -- Modulation of Drug Metabolism and Antiviral Therapies -- Modulation of Thiols and Other Low-Molecular-Weight Cofactors -- Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics -- Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier -- Glutathione Transport in the Kidneys -- Human Cytosolic Sulfotransferases.
520			_aRemarkable advances in molecular and cell biology and the development of novel in vitro model systems have greatly expanded our knowledge of the processes involved in metabolism and transport and led to numerous new therapeutic approaches. In Drug Metabolism and Transport: Molecular Methods and Mechanisms, well-established investigators describe their best experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low-molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy. The strategies detailed for transport phenomena cover the multidrug resistance proteins, the reduced folate carrier, the plasma membrane, and mitochondrial glutathione transporters, and can be applied to numerous other transport systems. Many chapters contain step-by-step methods for investigating metabolism and transport. Insightful and broad-ranging, Drug Metabolism and Transport: Molecular Methods and Mechanisms offers novice and experienced investigators alike a highly useful compendium of key strategies and approaches to successful research on drug metabolism and transport pathways.
700	1		_aLash, Lawrence H _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617374944
776	0	8	_iPrinted edition: _z9781588293244
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592598323 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2005
999			_c234900 _d234900