000			04241nam a22003735i 4500
001			234920
003			ES-VaUE
005			20221220020632.0
007			cr nn 008mamaa
008			121026s2012 xxu| s |||| 0|eng d
020			_a9781627030953
024	7		_a10.1007/978-1-62703-095-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aTRP Channels in Drug Discovery _bVolume II _cedited by Arpad Szallasi, Tamás Bíró.
250			_a1st edition 2012
264		1	_aTotowa, NJ _bHumana Press _c2012
300			_a1 recurso en línea (XIV, 489 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aTRPs to Cardiovascular Disease -- Anemic Zebrafish Models of Cardiomyopathy -- Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function -- Atherosclerosis Models with Cell-Mediated Calcification -- Models of Hypertension and Blood Pressure Recording -- Balloon Injury in Rats as a Model for Studying TRP Channel Contribution to Vascular Smooth Muscle Remodeling -- TRP Channels in the Brain -- Investigation of the Possible Role of TRP Channels in Schizophrenia -- Investigating Diseases of Dopaminergic Neurons and Melanocytes Using Zebrafish -- A Practical Guide to Evaluating Anxiety-Related Behavior in Rodents -- Rodent Models of Conditioned Fear: Behavioral Measures of Fear and Memory -- Chick Anxiety-Depression Screening Model -- A Clinically Relevant Thromboembolic Stroke Model in the Aged Rat -- Use of Cell-Stretch System to Examine the Characteristics of Mechanosensor Channels: Axonal Growth/Neuroregeneration Studies -- Methods in Neuronal Growth Cone Biology -- Transient Receptor Potential Channels and Pruritus -- Skin Sensitivity Studies -- Hair Follicle Culture -- Animal Models for Type 1 Diabetes -- Type 2 Diabetes Models -- Using Diet to Induce Metabolic Disease in Rodents -- Rodent Models to Evaluate Anti-Obesity Drugs -- Experimental Colitis Models -- Tumor Xenograft Models to Study the Role of TRP Channels in Tumorigenesis -- Methods to Study Thermonociception in Rodents -- Methods for the Assessment of Heat Perception in Humans -- Collagen Antibody-Induced Arthritis (CAIA): A Disease-Relevant Model for Studies of Persistent Joint Pain -- Animal Models of Muscular Dystrophy.
520			_aRecent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.  TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.  Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders.  Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.   Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
700	1		_aSzallasi, Arpad _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBíró, Tamás _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781627030946
776	0	8	_iPrinted edition: _z9781627030960
776	0	8	_iPrinted edition: _z9781493960668
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-62703-095-3 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2012
999			_c234920 _d234920