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001			234924
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007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9781597453509
024	7		_a10.1007/978-1-59745-350-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aCytokines in Human Health _bImmunotoxicology, Pathology, and Therapeutic Applications _cedited by Robert V. House, Jacques Descotes.
250			_a1st edition 2007
264		1	_aTotowa, NJ _bHumana Press _c2007
300			_a1 recurso en línea (X, 366 páginas) _b21 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_ato Cytokines as Targets for Immunomodulation -- Cytokine Measurement Tools for Immunotoxicology -- The Relevance of the T1/T2 Paradigm in Immunotoxicology -- Microbial Exploitation and Subversion of the Human Chemokine Network -- The Use of Cytokines in the Identification and Characterization of Chemical Allergens -- Inflammatory Cytokines and Lung Toxicity -- Cytokine Polymorphisms and Relationship to Disease -- Effects of Drugs of Abuse on Cytokine Responses -- Preclinical Approaches for the Safety Assessment of Cytokines -- Flu-Like Syndrome and Cytokines -- Cytokine-Induced Vascular Leak Syndrome -- Cytokines and Autoimmune Diseases -- Evaluation of Antibodies in Clinical Trials of Cytokines -- Cytokines and Pharmacokinetic Drug Interactions -- Evaluation of the Immunological Effects of Cytokines Administered to Patients With Cancer -- Clinical Adverse Effects of Cytokines on the Immune System.
520			_aCytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. The first section of the book is devoted to basic concepts of cytokine biology, especially as this relates to the practice of immunotoxicology. Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules. The second section provides a broad understanding of the range of cytokine activity in human disease, describing methods for assessing cytokine immunotoxicity. In the third and final section of the book, the increasingly important use of cytokines as therapeutics is explored in detail. This section includes examinations into the effects of cytokines on the immune system and in treating cancer. Timely and comprehensive, Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications will serve as both a primer and a starting point for a more detailed investigation of the role these fascinating biological regulators play in human health and disease.
700	1		_aHouse, Robert V _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aDescotes, Jacques _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617375866
776	0	8	_iPrinted edition: _z9781588294678
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-59745-350-9 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2007
999			_c234924 _d234924