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020 _a9781617799341
024 7 _a10.1007/978-1-61779-934-1
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
245 1 0 _aLC-MS in Drug Analysis
_bMethods and Protocols
_cedited by Loralie J. Langman, Christine L. H. Snozek.
250 _a1st edition 2012
264 1 _aTotowa, NJ
_bHumana Press
_c2012
300 _a1 recurso en línea (X, 224 páginas)
_b27 ilustraciones, 5 ilustraciones a color
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aMethods in Molecular Biology
_x1940-6029
_v902
505 0 _aAn Introduction to Drug Testing - The Expanding Role of Mass Spectrometry -- LC-MS vs. GC-MS, Online Extraction Systems, Advantages of Technology for Drug Screening Assays -- LC-MS/MS Techniques for High Volume Screening of Drugs of Abuse and Target Drug Quantitation in Urine/Blood Matrices -- Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry -- Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques -- Synthetic Opioid Analysis by LC-MS/MS -- The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection -- Cocaine and Metabolites by LC-MS/MS -- Quantitation of Amphetamine Type Stimulants by LC-MS/MS -- Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control -- LC-MS/MS Screen for Xenobiotics and Metabolites -- Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS -- Hypoglycemic Agent Screening by LC-MS/MS -- LC-MS/MS Method for the Detection of Common Laxatives -- Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS) -- Quantification of Tricyclic Antidepressants Using UPLC-MS/MS -- Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS -- Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry -- Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS.
520 _aLiquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance.  The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques.  The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents.  Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.
700 1 _aLangman, Loralie J
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aSnozek, Christine L. H
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 0 8 _iPrinted edition:
_z9781617799334
776 0 8 _iPrinted edition:
_z9781617799358
776 0 8 _iPrinted edition:
_z9781493961993
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-61779-934-1
_z(usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
988 _aSpringer_Protocols_2012
999 _c234952
_d234952