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020 _a9781597451598
024 7 _a10.1007/978-1-59745-159-8
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
245 1 0 _aCardiovascular Disease, Volume 1
_bGenetics
_cedited by Qing Wang.
250 _a1st edition 2007
264 1 _aTotowa, NJ
_bHumana Press
_c2007
300 _a1 recurso en línea (XII, 238 páginas)
_b154 ilustraciones, 11 ilustraciones a color
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aMethods in Molecular Medicine
_x1940-6037
_v128
505 0 _aCytogenetic Analysis of Cardiovascular Disease -- Fluorescence In Situ Hybridization in Cardiovascular Disease -- Comparative Genomic Hybridization by Microarray for the Detection of Cytogenetic Imbalance -- Construction of Somatic Cell Hybrid Lines -- LINKAGE Programs -- SAGE Programs -- Linkage Analysis for Complex Diseases Using Variance Component Analysis -- Genome Resources and Comparative Analysis Tools for Cardiovascular Research -- Positional Cloning -- Positional Cloning -- Chromosome Substitution Strains -- Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms Conferring Risk of Myocardial Infarction -- Mutation Detection in Congenital Long QT Syndrome -- High-Throughput Single-Nucleotide Polymorphisms Genotyping -- Genotyping Single-Nucleotide Polymorphisms by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight-Based Mini-Sequencing.
520 _aCardiovascular disease is the leading cause of death in developed countries, but is quickly becoming an epidemic in such well-populated countries as China, India, and other developing nations. Cardiovascular research is the key to the prevention, diagnosis, and management of cardiovascular disease. Vigorous and cross-disciplinary approaches are required for successful card- vascular research. As the boundaries between different scientific disciplines, particularly in the life sciences, are weakening and disappearing, a successful investigator needs to be competent in many different areas, including genetics, cell biology, biochemistry, physiology, and structural biology. The newly developed field of molecular medicine is a cross-disciplinary science that seeks to comprehend disease causes and mechanisms at the molecular level, and to apply this basic research to the prevention, diagnosis, and treatment of diseases and disorders. This volume in the Methods in Molecular Medicine series, C- diovascular Disease, provides comprehensive coverage of both basic and the most advanced approaches to the study and characterization of cardiovascular disease. These methods will advance knowledge of the mechanisms, diagnoses, and treatments of cardiovascular disease. Cardiovascular Disease is a timely volume in which the theory and pr- ciples of each method are described in the Introduction section, followed by a detailed description of the materials and equipment needed, and step-by-step protocols for successful execution of the method. A notes section provides advice for potential problems, any modifications, and alternative methods.
700 1 _aWang, Qing
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 0 8 _iPrinted edition:
_z9781617376498
776 0 8 _iPrinted edition:
_z9781588295729
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-59745-159-8
_z(usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
988 _aSpringer_Protocols_2007
999 _c235016
_d235016