000			03926nam a22003735i 4500
001			235035
003			ES-VaUE
005			20221220020639.0
007			cr nn 008mamaa
008			120919s2012 xxu| s |||| 0|eng d
020			_a9781627030779
024	7		_a10.1007/978-1-62703-077-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aTRP Channels in Drug Discovery _bVolume I _cedited by Arpad Szallasi, Tamás Bíró.
250			_a1st edition 2012
264		1	_aTotowa, NJ _bHumana Press _c2012
300			_a1 recurso en línea (XI, 446 páginas) _b39 ilustraciones, 13 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aIntroduction to TRPs: A Quest for Novel Drug Targets -- TRP-Mediated Cytoskeletal Reorganization: Implications for Disease and Drug Development -- TRPA1 in Drug Discovery -- Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases -- TRPM2 Function and Potential as a Drug Target -- The Ca2+-Activated Monovalent Cation Selective Channels TRPM4 and TRPM5 -- The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis -- TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation -- TRPML Channels in Function, Disease, and Prospective Therapies -- The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1 -- TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities -- Nociceptive and Non-Nociceptive Roles of TRPV3 and Its "Druggability" -- TRPV4 and Drug Discovery -- TRP Expression and Function in the Lung Airways -- Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells -- Endotoxin-Induced Airway Inflammation and Asthma Models -- Enhanced Cough, Animal Models -- Capsaicin Inhalation Test in Man -- TRP Channels in the Genitourinary (GU) Tract -- Animal Models of Cystitis -- Overactive Bladder Models.
520			_aRecent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.  TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.  Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract.  Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.   Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
700	1		_aSzallasi, Arpad _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBíró, Tamás _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781627030762
776	0	8	_iPrinted edition: _z9781627030786
776	0	8	_iPrinted edition: _z9781493962815
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-62703-077-9 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2012
999			_c235035 _d235035