000			03913nam a22003735i 4500
001			235057
003			ES-VaUE
005			20221220020641.0
007			cr nn 008mamaa
008			160924s2016 xxu| s |||| 0|eng d
020			_a9781493963553
024	7		_a10.1007/978-1-4939-6355-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aAntiepileptic Drug Discovery _bNovel Approaches _cedited by Alan Talevi, Luisa Rocha.
250			_a1st edition 2016
264		1	_aNew York, NY _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XI, 386 páginas) _b51 ilustraciones, 42 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aInflammatory Cytokines as Targets for Epilepsy Drug Therapy -- The Use of Anti-Inflammatory Drugs in Epilepsy -- Carbonic Anhydrase and Epilepsy -- Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs -- Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy? -- Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy -- Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity -- Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy -- Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery -- Gene Therapy in Epilepsy -- Human Brain Tissue as a Model for the Study of Epilepsy -- The Blood-Brain Barrier and the Design of New Antiepileptic Drugs -- Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates -- Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations -- Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations -- Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies -- Side Effects of Antiepileptic Drugs -- Network Pharmacology and Epilepsy -- The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development.
520			_aThis thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.
700	1		_aTalevi, Alan _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aRocha, Luisa _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493963539
776	0	8	_iPrinted edition: _z9781493963546
776	0	8	_iPrinted edition: _z9781493981748
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-6355-3 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2016
999			_c235057 _d235057