000			04080nam a22003615i 4500
001			235101
003			ES-VaUE
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007			cr nn 008mamaa
008			100301s2009 xxu| s |||| 0|eng d
020			_a9781603278119
024	7		_a10.1007/978-1-60327-811-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aTumor Biomarker Discovery _bMethods and Protocols _cedited by Michael A. Tainsky.
250			_a1st edition 2009
264		1	_aTotowa, NJ _bHumana Press _c2009
300			_a1 recurso en línea (XI, 332 páginas) _b52 ilustraciones, 16 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v520
505	0		_aIdentification of Tumor-Associated Antigens as Diagnostic and Predictive Biomarkers in Cancer -- Autoantibodies Against Cancer Antigens -- Discovery of Antibody Biomarkers Using Protein Microarrays of Tumor Antigens Cloned in High Throughput -- Analysis of Glycans on Serum Proteins Using Antibody Microarrays -- Glycoproteomic Analysis by Two-Dimensional Electrophoresis -- All-Liquid Separations, Protein Microarrays, and Mass Spectrometry to Interrogate Serum Proteomes: An Application to Serum Glycoproteomics -- Reverse-Phase Protein Microarrays for Theranostics and Patient Tailored Therapy -- Serum Proteomics Using Mass Spectrometry -- Hormones as Biomarkers: Practical Guide to Utilizing Luminex Technologies for Biomarker Research -- High-Throughput Analysis of Serum Antigens Using Sandwich ELISAs on Microarrays -- Tissue Microarrays as a Tool in the Discovery and Validation of Tumor Markers -- Quantitative, Fluorescence-Based In-Situ Assessment of Protein Expression -- Tumor Marker Discovery by Expression Profiling RNA from Formalin Fixed Paraffin Embedded Tissues -- High-Throughput Mutation Screening Using a Single Amplification Condition -- DNA Sequencing of Cancer-Related Genes for Biomarker Discovery -- Analysis of Loss of Heterozygosity in Circulating DNA -- Pharmacogenomics -- Study Designs in Genetic Epidemiology -- Developing Classifiers for the Detection of Cancer Using Multi-Analytes -- Metabolomics of Cancer -- MRI and MRS of Human Brain Tumors -- Magnetic Resonance Spectroscopy of Living Tissues.
520			_aThrough a variety of mechanisms, cancer cells provide the biomarker material that can lead to their own detection, which then grants clinicians the opportunity for non-invasive body fluid and tissue analysis able to indicate the presence of tumors or the level of tumor burden. In Tumor Biomarker Discovery: Methods and Protocols, experts in the field present detailed chapters focused on the use and development of panels of biomarker analytes while covering subjects such as nucleic acids and protein-based technologies, metabolic profiling by analytic means or spectroscopy, as well as study designs for biomarker discovery and validation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials or reagents, step-by-step laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Tumor Biomarker Discovery: Methods and Protocols is an ideal guide to the technologies that can be used to discover and validate tumor biomarker panels suitable for the presymptomatic early detection of cancer.
700	1		_aTainsky, Michael A _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781603278126
776	0	8	_iPrinted edition: _z9781617379154
776	0	8	_iPrinted edition: _z9781603278102
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60327-811-9 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2009
999			_c235101 _d235101