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001			235123
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008			100301s2008 xxu| s |||| 0|eng d
020			_a9781597454193
024	7		_a10.1007/978-1-59745-419-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aPeptide-Based Drug Design _cedited by Laszlo Otvos.
250			_a1st edition 2008
264		1	_aTotowa, NJ _bHumana Press _c2008
300			_a1 recurso en línea (XI, 303 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v494
505	0		_aPeptide-Based Drug Design: Here and Now -- Strategies for the Discovery, Isolation, and Characterization of Natural Bioactive Peptides from the Immune System of Invertebrates -- Sequence Analysis of Antimicrobial Peptides by Tandem Mass Spectrometry -- The Spot Technique: Synthesis and Screening of Peptide Macroarrays on Cellulose Membranes -- Analysis of A? Interactions Using ProteinChip Technology -- NMR in Peptide Drug Development -- Molecular Dynamics Simulations of Peptides -- Short Linear Cationic Antimicrobial Peptides: Screening, Optimizing, and Prediction -- Investigating the Mode of Action of Proline-Rich Antimicrobial Peptides Using a Genetic Approach: A Tool to Identify New Bacterial Targets Amenable to the Design of Novel Antibiotics -- Serum Stability of Peptides -- Preparation of Glycosylated Amino Acids Suitable for Fmoc Solid-Phase Assembly -- Synthesis of O-Phosphopeptides on Solid Phase -- Peptidomimetics: Fmoc Solid-Phase Pseudopeptide Synthesis -- Synthesis of Toll-Like Receptor-2 Targeting Lipopeptides as Self-Adjuvanting Vaccines -- Synthesis of a Multivalent, Multiepitope Vaccine Construct -- Cysteine-Containing Fusion Tag for Site-Specific Conjugation of Therapeutic and Imaging Agents to Targeting Proteins.
520			_aDue to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular Biology™ series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.
700	1		_aOtvos, Laszlo _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781603278720
776	0	8	_iPrinted edition: _z9781617378690
776	0	8	_iPrinted edition: _z9781588299901
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-59745-419-3 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2008
999			_c235123 _d235123