000			04467nam a22003615i 4500
001			235187
003			ES-VaUE
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007			cr nn 008mamaa
008			120215s2012 xxu| s |||| 0|eng d
020			_a9781617795619
024	7		_a10.1007/978-1-61779-561-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aPain Research _bMethods and Protocols _cedited by Z. David Luo.
250			_a2nd edition 2012
264		1	_aTotowa, NJ _bHumana Press _c2012
300			_a1 recurso en línea (XI, 287 páginas) _b66 ilustraciones, 3 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v851
505	0		_aAdvancements in Pain Research -- Genomic Methods for Clinical and Translational Pain Research -- Two-Dimensional Gel Electrophoresis: Discovering Neuropathic Pain-Associated Synaptic Biomarkers in Spinal Cord Dorsal Horn -- Whole-Cell Patch-Clamp Recordings on Spinal Cord Slices -- Whole-Cell Recording in Isolated Primary Sensory Neurons -- Indwelling Supradural Catheters for Induction of Facial Allodynia: Surgical Procedures, Application of Inflammatory Stimuli, and Behavioral Testing -- An Experimental Model of Headache-Related Pain -- A Rodent Model of Trigeminal Neuralgia -- New Models of Experimental Parotitis and Parotid Gland Distension in Rats -- A Rat Pain Model of Facial Cancer -- Orofacial Pain Models and Behavior Assessment -- Unilateral T13 and L1 Dorsal Root Avulsion: Methods for a Novel Model of Central Neuropathic Pain -- A Lumbosacral Ventral Root Avulsion Injury and Repair Model for Studies of Neuropathic Pain in Rats -- A Rat Chronic Pain Model of Spinal Cord Contusion Injury -- The Spared Nerve Injury Model of Neuropathic Pain -- A New Rat Pain Model of Thrombus-Induced Ischemia -- Rat Models of Pancreatitis Pain -- The Monosodium Iodoacetate Model of Osteoarthritis Pain in The Rat -- K/BxN Serum Transfer Arthritis as a Model of Inflammatory Joint Pain -- A New Rat Model of Bone Cancer Pain -- Exposure of the Dorsal Root Ganglion to Pulsed Radiofrequency Current in a Neuropathic Pain Model of Peripheral Nerve Injury.
520			_aThe advancements of medical technology, improvements in medical care, and increased patients' life span make pain research and related drug development high priorities for both the research community and pharmaceutical companies. Rapid development of basic science research tools, such as techniques of flurometric labeling, genomic and proteomic high throughput screening, and genetically modified animals, promotes the swift acceleration of pain research to a stage allowing integrated investigations of pain processing mechanisms at the single cell and/or molecule level, and in a spatially and temporally controlled manner.  Using multidisciplinary approaches, we can dissect the complicity of the sensory circuits connecting peripheral stimulation to maladaptive changes in the sensory pathways as well as pain perceptions at the central nervous system. Pain Research: Methods and Protocols, Second Edition provides advanced techniques and animal models that are critical for integrated pain research. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and accessible, Pain Research: Methods and Protocols, Second Edition serves as an ideal guide to novice pain researchers who may not have extensive experiences in the field, or to experienced pain researchers who would like to expand their research in new directions and/or to new mechanisms in different models. .
700	1		_aLuo, Z. David _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617795602
776	0	8	_iPrinted edition: _z9781617795626
776	0	8	_iPrinted edition: _z9781493960958
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-61779-561-9 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2012
999			_c235187 _d235187