000			03267nam a22003615i 4500
001			235212
003			ES-VaUE
005			20221220020651.0
007			cr nn 008mamaa
008			100301s2008 xxu| s |||| 0|eng d
020			_a9781603270489
024	7		_a10.1007/978-1-60327-048-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aEssential Concepts in Toxicogenomics _cedited by Donna L. Mendrick, William B. Mattes.
250			_a1st edition 2008
264		1	_aTotowa, NJ _bHumana Press _c2008
300			_a1 recurso en línea (XI, 277 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v460
505	0		_aToxicogenomics and Classic Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity -- Use of Traditional End Points and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic Toxicology -- Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications -- Role of Statistics in Toxicogenomics -- Predictive Toxicogenomics in Preclinical Discovery -- In Vivo Predictive Toxicogenomics -- Bioinformatics: Databasing and Gene Annotation -- Microarray Probe Mapping and Annotation in Cross-Species Comparative Toxicogenomics -- Toxicogenomics in Biomarker Discovery -- From Pharmacogenomics to Translational Biomarkers -- Public Consortium Efforts in Toxicogenomics -- Applications of Toxicogenomics to Nonclinical Drug Development: Regulatory Science Considerations.
520			_aThe field of toxicogenomics has been growing quickly, yet with rapid growth comes the need to periodically reflect on the nature of the field. Essential Concepts in Toxicogenomics collects reviews, opinion pieces and case studies from the leading experts in this dynamic field with a focus on its application to pharmaceuticals. Topics covered include issues that affect the quality of toxicogenomics experiments, statistical approaches to their data analysis, the use of such data to build toxicogenomic models, and the utilization of genomics to identify biomarkers within the preclinical and clinical arenas. Although not in the standard Methods in Molecular Biology™ series format, this volume retains the practicality and usefulness of the highly successful series. Informative and cutting-edge, Essential Concepts in Toxicogenomics is an ideal resource for pharmaceutical companies, chemical manufacturers, toxicologists, and all who must keep up-to-date on progress in this vital and important field.
700	1		_aMendrick, Donna L _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aMattes, William B _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617376887
776	0	8	_iPrinted edition: _z9781588296382
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60327-048-9 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2008
999			_c235212 _d235212