000			03955nam a22003615i 4500
001			235249
003			ES-VaUE
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007			cr nn 008mamaa
008			160316s2016 xxu| s |||| 0|eng d
020			_a9781493932924
024	7		_a10.1007/978-1-4939-3292-4 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aPoliovirus _bMethods and Protocols _cedited by Javier Martín.
250			_a1st edition 2016
264		1	_aNew York, NY _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XI, 341 páginas) _b75 ilustraciones, 58 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v1387
505	0		_aAn Introduction to Poliovirus: Pathogenesis, Vaccination and the Endgame for Global Eradication -- Poliovirus Laboratory Based Surveillance: An Overview -- Isolation and Characterisation of Enteroviruses from Clinical Samples -- Isolation and Characterisation of Poliovirus in Cell Culture Systems -- Molecular Characterization of Polio from Environmental Samples - ISSP, The Israeli Sewage Surveillance Protocol -- Quality Assurance in the Polio Laboratory. Cell Sensitivity and Cell Authentication Assays -- A Transgenic Mouse Model of Poliomyelitis -- Standardized Methods for Detection of Poliovirus Antibodies -- Molecular Properties of Poliovirus Isolates: Nucleotide Sequence Analysis,Typing by PCR and Real-time RT-PCR -- Isolation and Characterization of Vaccine-Derived Polioviruses, Relevance for the Global Polio Eradication Initiative -- Phylogenetic Analysis of Poliovirus Sequences -- Generation of Infectious Poliovirus with Altered Genetic Information from Cloned cDNA -- A Rapid Method for Engineering Recombinant Polioviruses or Other Enteroviruses -- Methods to Monitor Molecular Consistency of Oral Polio Vaccine -- Methods for the Quality Control of Inactivated Poliovirus Vaccines -- Measuring Poliovirus Antigenicity by Surface Plasmon Resonance. Application for Potency Indicating Assays -- Identification and Analysis of Antiviral Compounds against Poliovirus.
520			_aThis volume introduces the reader to the field of systems medicine by defining its terminology, and describing how established computational methods from bioinformatics and systems biology can be taken forward to establish integrative systems medicine approaches. Systems Medicine provides an outlook on the role that systems medicine may or should play in various medical fields. Describing different facets of the systems medicine approach in action, including examples related to human metabolism, chronic obstructive pulmonary disease, the RNAs in biomedicine and regenerative stem cell medicine. Chapters also introduce tools, resources and methodologies from bioinformatics and systems biology, and shows how to apply these in a systems medicine project. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, and discuss experimental and computational approaches, methods, and tools that should be considered for a successful systems medicine project. Systems Medicine aims to motivate and provide guidance for collaborations across disciplines to tackle today's challenges related to human health and well-being.
700	1		_aMartín, Javier _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493932917
776	0	8	_iPrinted edition: _z9781493932931
776	0	8	_iPrinted edition: _z9781493980130
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-3292-4 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2016
999			_c235249 _d235249