000			03559nam a22003735i 4500
001			235254
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007			cr nn 008mamaa
008			110301s2011 xxu| s |||| 0|eng d
020			_a9781617790317
024	7		_a10.1007/978-1-61779-031-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aPhotosensitive Molecules for Controlling Biological Function _cedited by James J. Chambers, Richard H. Kramer.
250			_a1st edition 2011
264		1	_aTotowa, NJ _bHumana Press _c2011
300			_a1 recurso en línea (XIV, 298 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v55
505	0		_aIntroduction to Part I: Caged Neurotransmitters -- Targeting and Excitation of Photoactivatable Molecules: Design Considerations for Neurophysiology Experiments -- Are Caged Compounds Still Useful? -- Chromophores for the Delivery of Bioactive Molecules with Two-Photon Excitation -- Introduction to Part II: Natural Photosensitive Proteins -- Light-Activated Ion Pumps and Channels for Temporally-Precise Optical Control of Activity in Genetically-Targeted Neurons -- Vertebrate and Invertebrate Rhodopsins: Light Control of G Protein Signaling -- Restoring Visual Function after Photoreceptor Degeneration: Ectopic Expression of Photosensitive Proteins in Retinal Neurons -- Introduction to Part III: Small Molecule Photoswitches -- Photoswitch Design -- Photoswitchable Voltage-Gated Ion Channels -- Optical Manipulation of Protein Activity and Protein Interactions Using Caged Proteins and Optical Switch Protein Conjugates -- Structure-Based Design of Light-Controlled Proteins -- Photoswitchable Ligand-Gated Ion Channels.
520			_aThe development of new photochemical tools, some synthesized by chemists and some provided by nature, is rapidly changing the way neurobiological research is performed in the modern laboratory.  In Photosensitive Molecules for Controlling Biological Function, expert researchers in the field examine the most cutting-edge tools currently available.  Divided into three sections, this detailed compendium features techniques involving natural photosensitive proteins, caged neurotransmitters, and small molecule photoswitches that bestow light sensitivity on ion channels and receptors.  Written for the Neuromethods series, this volume features the type of meticulous description and implementation advice that is crucial for getting optimal results in the lab.   Authoritative and practical, Photosensitive Molecules for Controlling Biological Function provides an unbiased comparison of the various photochemical tools currently available for controlling neuronal activity in order to aid scientists in the vital goal of choosing the right tools for the right job.
700	1		_aChambers, James J _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aKramer, Richard H _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617790300
776	0	8	_iPrinted edition: _z9781617790324
776	0	8	_iPrinted edition: _z9781493957286
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-61779-031-7 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2011
999			_c235254 _d235254