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008			100301s2003 xxu| s |||| 0|eng d
020			_a9781592593644
024	7		_a10.1385/159259364X _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aFunctional Genomics _cedited by Michael J. Brownstein, Arkady Khodursky.
250			_a1st edition 2003
264		1	_aTotowa, NJ _bHumana Press _c2003
300			_a1 recurso en línea (XII, 260 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v224
505	0		_aFabrication of cDNA Microarrays -- Nylon cDNA Expression Arrays -- Plastic Microarrays -- Preparing Fluorescent Probes for Microarray Studies -- Escherichia coli Spotted Double-Strand DNA Microarrays -- Isolation of Polysomal RNA for Microarray Analysis -- Parallel Analysis of Gene Copy Number and Expression Using cDNA Microarrays -- Genome-wide Mapping of Protein-DNA Interactions by Chromatin Immunoprecipitation and DNA Microarray Hybridization -- Statistical Issues in cDNA Microarray Data Analysis -- Experimental Design to Make the Most of Microarray Studies -- Statistical Methods for Identifying Differentially Expressed Genes in DNA Microarrays -- Detecting Stable Clusters Using Principal Component Analysis -- Clustering in Life Sciences -- A Primer on the Visualization of Microarray Data -- Microarray Databases.
520			_aAs high-throughput methods become more available and routine, experimentalists and theoreticians must be prepared to take advantage of the analytical power these methods offer. In Functional Genomics: Methods and Protocols, leading experimentalists-many pioneers in the field-describe in step-by-step detail robust methods for microarray-based studies and provide expert guidance in optimal data analysis and informatics. Drawing on insights derived from their long experience in biology, neurobiology, cell biology, molecular biology, and statistics, the authors review each of the key methods and analytical techniques used in functional genomics. On the methods side, this includes proven techniques for monitoring subcellular RNA localization en masse, for mapping chromosomes at the resolution of a single gene, and for surveying the steady-state genome-wide distribution of DNA binding proteins in vivo. For those workers dealing with massive data sets, the book discusses the methodological aspects of data analysis and informatics in the design of microarray experiments, the choice of test statistic, and the assessment of observational significance, data reduction, and clustering. Additional chapters outline the many available approaches to data visualization and storage so crucial to the successful mining and examination of experimental results. Timely and cutting-edge, Functional Genomics: Methods and Protocols offers novice and advanced investigators in all biological fields a collection of highly practical, readily reproducible methods, data analysis techniques, and experimental design criteria that will ensure safe passage through one of the most demanding and fastest growing fields today.
700	1		_aBrownstein, Michael J _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aKhodursky, Arkady _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617374746
776	0	8	_iPrinted edition: _z9781489938480
776	0	8	_iPrinted edition: _z9781588292919
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/159259364X _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2003
999			_c235365 _d235365