000			03820nam a22003735i 4500
001			235590
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007			cr nn 008mamaa
008			150731s2016 xxu| s |||| 0|eng d
020			_a9781493928583
024	7		_a10.1007/978-1-4939-2858-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aMuscarinic Receptor: From Structure to Animal Models _cedited by Jaromir Myslivecek, Jan Jakubik.
250			_a1st edition 2016
264		1	_aNew York, NY _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XII, 287 páginas) _b77 ilustraciones, 42 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aNeuromethods _x1940-6045 _v107
505	0		_aTowards the Crystal Structure Determination of Muscarinic Acetylcholine Receptors -- Homology Modeling and Docking Evaluation of Human Muscarinic Acetylcholine Receptors -- Radioligand Binding at Muscarinic Receptors -- Binding Method for Detection of Muscarinic Acetylcholine Receptors in Receptor's Natural Environment -- Use of Antibodies in the Research on Muscarinic Receptor Subtypes -- Allosteric Modulation of Muscarinic Receptors -- Subcellular and Synaptic Localization of Muscarinic Receptors in Neurons Using High-Resolution Electron Microscopic Preembedding Immunogold Technique -- Investigation of Muscarinic Receptors by Fluorescent Techniques -- Autoradiography Assessment of Muscarinic Receptors in the Central Nervous System -- Imaging of Muscarinic Receptors in the Central Nervous System -- Detection of Non-Neuronal Acetylcholine -- Utilization of Superfused Cerebral Slices in Probing Muscarinic Receptor Autoregulation of Acetylcholine Release -- Regulation of Heart Contractility by M2 and M3 Muscarinic Receptors: Functional Studies using Muscarinic Receptor Knockout Mouse -- Muscarinic Receptor Gene Transfections and In Vivo Dopamine Electrochemistry: Muscarinic Receptor Control of Dopamine-Dependent Reward and Locomotion.
520			_aThis volume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and computer‑based approaches to study muscarinic receptors. Muscarinic Receptor: From Structure to Animal Models guides readers through binding techniques, protocols to investigate molecular properties of muscarinic receptors, protocols to study muscarinic receptors in the central nervous system using autoradiography and PET studies, and protocols on animals with knock-out and knock-in muscarinic genes to study role of muscarinic receptors in physiology and behavior. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.  Concise and easy-to-use, Muscarinic Receptor: From Structure to Animal Models aims to ensure successful results in the further study of this vital field.
700	1		_aMyslivecek, Jaromir _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aJakubik, Jan _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493928576
776	0	8	_iPrinted edition: _z9781493928590
776	0	8	_iPrinted edition: _z9781493949717
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-2858-3 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2016
999			_c235590 _d235590