000			03596nam a22003855i 4500
001			235663
003			ES-VaUE
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007			cr nn 008mamaa
008			160720s2016 xxu| s |||| 0|eng d
020			_a9781493937981
024	7		_a10.1007/978-1-4939-3798-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aG Protein-Coupled Receptor Kinases _cedited by Vsevolod V. Gurevich, Eugenia V. Gurevich, John J.G. Tesmer.
250			_a1st edition 2016
264		1	_aNew York, NY _bSpringer International Publishing _c2016
300			_a1 recurso en línea (XI, 329 páginas) _b36 ilustraciones, 33 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aG Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery -- Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7 -- Visual G Protein-Coupled Receptor Kinases -- Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily -- "Barcode" and Differential Effects of GPCR Phosphorylation by Different GRKs -- Cell-Type Specific GRK2 Interactomes: Physiopathological Implications -- Differential Regulation of IGF-1 and Insulin Signaling by GRKs -- Differential Control of Potassium Channel Activity by GRK2 -- Critical Role of GRK2 in the Prevention of Chronic Pain -- Roles of GRK Dysfunction in Alzheimer's Pathogenesis -- Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases -- G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation -- GRK Roles in C. elegans -- Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway.
520			_aThis collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.
700	1		_aGurevich, Vsevolod V _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aGurevich, Eugenia V _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aTesmer, John J.G _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493937967
776	0	8	_iPrinted edition: _z9781493937974
776	0	8	_iPrinted edition: _z9781493981427
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-3798-1 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2016
999			_c235663 _d235663