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008			140430s2014 xxu| s |||| 0|eng d
020			_a9781493905218
024	7		_a10.1007/978-1-4939-0521-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aIn Vitro Toxicology Systems _cedited by Anna Bal-Price, Paul Jennings.
250			_a1st edition 2014
264		1	_aNew York, NY _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XXI, 583 páginas) _b64 ilustraciones, 54 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Pharmacology and Toxicology _x1940-6053
505	0		_aThe Past, Present and Future of Chemical Risk Assessment.- In Vitro Systems for Hepatotoxicity Testing -- In Vitro Methods for Cardiotoxicity Testing -- Renal Cell Culture -- Cellular Models for In Vitro Lung Toxicology -- In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints -- Blood Brain Barrier In Vitro Models and Their Applications in Toxicology -- Ocular Toxicity -- In Vitro Models for Ototoxic Research -- Dermal Toxicity: Skin Sensitization -- Immunotoxicity -- Reproductive Toxicity -- Evaluating Endocrine Disruption In Vitro -- Current and Emerging In Vitro Methods for Genotoxicity and Carcinogenicity -- Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening -- Human Stem/Progenitor Cell-Based Assays for Neurodevelopmental Toxicity Testing -- High Content Imaging Approaches for In Vitro Toxicology -- Application of Omics Technologies to In Vitro Toxicology -- Stress Response Pathways -- Translational Biomarkers, In Vitro and In Vivo -- Nanotoxicology -- Consideration of Metabolism in In Vitro Cellular Systems -- In Vitro Approaches to Predictive Biokinetics -- Extrapolating In Vitro Results to Predict Human Toxicity -- Considerations in the Development of In Vitro Toxicity Testing Methods Intended for Regulatory Use.
520			_aIn Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
700	1		_aBal-Price, Anna _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aJennings, Paul _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493905225
776	0	8	_iPrinted edition: _z9781493905201
776	0	8	_iPrinted edition: _z9781493954803
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-0521-8 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2014
999			_c235678 _d235678