000			04295nam a22003615i 4500
001			235696
003			ES-VaUE
005			20221220020721.0
007			cr nn 008mamaa
008			100301s2002 xxu| s |||| 0|eng d
020			_a9781592592852
024	7		_a10.1385/1592592856 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aCombinatorial Library _bMethods and Protocols _cedited by Lisa B. English.
250			_a1st edition 2002
264		1	_aTotowa, NJ _bHumana Press _c2002
300			_a1 recurso en línea (XI, 383 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v201
505	0		_aLibrary Synthesis and Quality Control -- Using a Noncovalent Protection Strategy to Enhance Solid-Phase Synthesis -- Quality Control of Solid-Phase Synthesis by Mass Spectrometry -- Preparation of Encoded Combinatorial Libraries for Drug Discovery -- Simple Tools for Manual Parallel Solid Phase Synthesis -- Cleavage of Compounds from Solid Phase by Gaseous Reagents -- Synthesis of DNA-Binding Polyamides -- The Preparation of Phenyl-stilbene Derivatives Using the Safety Catch Linker -- Host-Guest Chemistry -- Automated Structure Verification of Small Molecules Libraries Using 1D and 2D NMR Techniques -- Rapid Liquid-Phase Combinatorial Synthesis of Heterocyclic Libraries -- Soluble Polymer-Supported Methods for Combinatorial and Organic Synthesis -- Analytical Methods for Optimization and Quality Control of Combinatorial Synthesis -- Library Purification and Screening -- Resolving Racemic Mixtures Using Parallel Combinatorial Libraries -- Ligand Libraries for the Extraction of Metal Ions -- Automated Liquid-Liquid Extraction and Ion-Exchange Solid-Phase Extraction for Initial Purification -- On-Bead and Solution Screening Approaches for Genomically Derived Targets -- Computational Library Design -- Design of Virtual Combinatorial Libraries -- Approaches to Library Design for Combinatorial Chemistry -- Reagent-Based and Product-Based Computational Strategies in Library Design -- Designing Combinatorial Libraries for Efficient Screening -- Application of Neural Networks to Large Dataset QSAR, Virtual Screening, and Library Design.
520			_aBy significantly increasing the number of targets available for drug discovery, the Human Genome and Proteome projects have made the use of combinatorial libraries essential to developing and optimizing drug candidate molecules more rapidly. Lisa English and a panel of expert researchers have collected in Combinatorial Library Methods and Protocols a novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR. A variety of well-known computational approaches are provided to meet the information management challenge of multiple biological assays. Each readily reproducible technique includes detailed step-by-step instructions and helpful notes on troubleshooting and avoiding pitfalls. Timely and highly practical, Combinatorial Library Methods and Protocols makes available for all drug discovery researchers all the powerful combinatorial chemistry tools that are increasing the number of candidate compounds and speeding the process of drug discovery and development today.
700	1		_aEnglish, Lisa B _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781489938992
776	0	8	_iPrinted edition: _z9780896039803
776	0	8	_iPrinted edition: _z9781489938985
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592592856 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2002
999			_c235696 _d235696