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020 _a9781493933471
024 7 _a10.1007/978-1-4939-3347-1
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
245 1 0 _aCancer Drug Resistance
_bOverviews and Methods
_cedited by Jose Rueff, António Sebastião Rodrigues.
250 _a1st edition 2016
264 1 _aNew York, NY
_bSpringer International Publishing
_c2016
300 _a1 recurso en línea (XIII, 314 páginas)
_b47 ilustraciones, 37 ilustraciones a color
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aMethods in Molecular Biology
_x1940-6029
_v1395
505 0 _aCancer Drug Resistance: A Brief Overview from a Genetic Viewpoint -- Classical and Targeted Anti-Cancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance.- In Vitro Methods for Studying the Mechanisms of Resistance to DNA Damaging Therapeutic Drugs.- In Vitro Approaches to Study Regulation of Hepatic Cytochrome P450 (CYP) 3A Expression by Paclitaxel and Rifampicin.- Uptake and Permeability Studies to Delineate the Role of Efflux Transporters.- Dynamics of Expression of Drug Transporters: Methods for Appraisal.- Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter.- Resistance to Targeted Therapies in Breast Cancer.- MicroRNAs and Cancer Drug Resistance -- The Role of MicroRNAs in Resistance to Current Pancreatic Cancer Treatment: Translational Studies and Basic Protocols for Extraction and PCR Analysis.- Methods for Studying MicroRNAs Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer Tissues.- The Regulatory Role of Long Non-Coding RNAs in Cancer Drug Resistance.- Cancer Exosomes as Mediators of Drug Resistance -- Isolation and Characterization of Cancer Stem Cells from Primary Head and Neck Squamous Cell Carcinoma Tumors.- Clinical and Molecular Methods in Drug Development: Neoadjuvant Systemic Therapy in Breast Cancer as a Model.- Proteo mics in the Assessment of the Therapeutic Response of Anti-Neoplastic Drugs: Strategies and Practical Applications.- Managing Drug Resistance in Cancer: Role of Cancer Informatics.
520 _aThis volume discusses the latest advancements and technologies used in cancer drug resistance research. Cancer Drug Resistance: Overviews and Methods contains chapters that cover topics such as: studying the mechanics of resistance to DNA damaging therapeutic drugs; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; the role of microRNAs in current pancreatic cancer treatment; and cancer exosomes as mediators of drug resistance or clinical and molecular methods in drug development and the use of bioinformatics in the management of cancer drug resistance data. Written in the highly successful Methods in Molecular Biology series format, chapters include overviews of the main issues in cancer drug resistance and the respective mechanisms, as well as introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Drug Resistance: Overviews and Methods, is a valuable resource to researchers, oncobiologists and clinical oncologists or anyone else who is interested in the study of cancer and its drug resistances.
700 1 _aRueff, Jose
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aRodrigues, António Sebastião
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 0 8 _iPrinted edition:
_z9781493933457
776 0 8 _iPrinted edition:
_z9781493933464
776 0 8 _iPrinted edition:
_z9781493980277
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-3347-1
_z(usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
988 _aSpringer_Protocols_2016
999 _c235704
_d235704