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020 _a9781592590834
024 7 _a10.1385/1592590837
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
245 1 0 _aVaccine Adjuvants
_bPreparation Methods and Research Protocols
_cedited by Derek T. O'Hagan.
250 _a1st edition 2000
264 1 _aTotowa, NJ
_bHumana Press
_c2000
300 _a1 recurso en línea (X, 342 páginas)
_b
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
347 _aarchivo de texto
_bPDF
490 0 _aMethods in Molecular Medicine
_x1940-6037
_v42
505 0 _aAn Overview of Adjuvant Use -- Harmful and Beneficial Activities of Immunological Adjuvants -- Freund's Adjuvants -- Aluminum Compounds as Vaccine Adjuvants -- Poly(Lactide-Coglycolide) Microparticles As Vaccine Adjuvants -- Poly(Methyl Methacrylate) Nanoparticles As Vaccine Adjuvants -- Aqueous Formulation of Adjuvant-Active Nonionic Block Copolymers -- Liposomes As Immunological Adjuvants and Vaccine Carriers -- Immunopotentiating Reconstituted Influenza Virosomes (IRIVs) -- Cochleates for Induction of Mucosal and Systemic Immune Responses -- Virus-like Particles As Vaccine Adjuvants -- The Adjuvant MF59: A 10-Year Perspective Gary Ott, Ramachandran Radhakrishnan, -- Preparation of the Syntex Adjuvant Formulation (SAF, SAF-m, and SAF-1) -- The ISCOM™ Technology -- QS-21 Adjuvant -- MPL® Immunostimulant: Adjuvant Formulations -- Cytokines As Vaccine Adjuvants: The Use of Interleukin-2 -- DNA As an Adjuvant -- Transcutaneous Immunization -- Mutant Heat-Labile Entertoxins As Adjuvants for CTL Induction.
520 _aAdjuvants play a key role in controlling the efficacy of vaccines, through enhancing the immune response to vaccine antigens, including recombinant proteins, protein polysaccharide conjugates, synthetic peptides, or DNA. In Vaccine Adjuvants: Preparation Methods and Research Protocols, Derek T. O'Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, including suggestions why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. The methods, described in full detail, range from the simple mixing of an antigen with a preformed adjuvant, to a complex preparation process requiring the antigens to be physically associated, or entrapped within, an adjuvant formulation. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today's researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way. The use of the information in this book will promote the development of powerful new vaccines against infectious diseases and cancers, and may promote the development of products to ameliorate autoimmune disorders.
700 1 _aO'Hagan, Derek T
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
776 0 8 _iPrinted edition:
_z9781617371592
776 0 8 _iPrinted edition:
_z9780896037359
776 0 8 _iPrinted edition:
_z9781489941848
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592590837
_z(usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
988 _aSpringer_Protocols_2000
999 _c235710
_d235710