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007			cr nn 008mamaa
008			150218s2015 xxu| s |||| 0|eng d
020			_a9781493924288
024	7		_a10.1007/978-1-4939-2428-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aClinical Epidemiology _bPractice and Methods _cedited by Patrick S. Parfrey, Brendan J. Barrett.
250			_a2nd edition 2015
264		1	_aNew York, NY _bSpringer International Publishing _c2015
300			_a1 recurso en línea (XIII, 533 páginas) _b52 ilustraciones, 7 ilustraciones a color
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v1281
505	0		_aOn Framing the Research Question and Choosing the Appropriate Research Design -- Research Ethics for Clinical Researchers -- Definitions of Bias in Clinical Research -- Longitudinal Studies 1: Determination of Risk -- Longitudinal Studies 2: Modeling Data Using Multivariate Analysis -- Longitudinal Studies 3: Data Modeling Using Standard Regression Models and Extensions -- Longitudinal Studies 4: Matching Strategies to Evaluate Risk -- Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease -- Randomized Controlled Trials 1: Design -- Randomized Controlled Trials 2: Analysis -- Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes -- Randomized Controlled Trials 4: Biomarkers and Surrogate Outcomes -- Randomized Controlled Trials 5: Determining the Sample Size and Power for Clinical Trials and Cohort Studies -- Randomized Controlled Trials 6: On Contamination and Estimating the Actual Treatment Effect -- Randomized Controlled Trials 7: Analysis and Interpretation of Quality of Life Scores -- Randomized Controlled Trials 8: Planning, Monitoring, and Execution -- Evaluation of Diagnostic Tests -- Qualitative Research in Clinical Epidemiology -- Health Economics in Clinical Research -- Clinical Genetic Research 1: Bias -- Clinical Genetic Research 2:  Genetic Epidemiology of Complex Phenotypes -- Clinical Genetic Research 3: Genetics ELSI (Ethical, Legal and Social Issues) Research -- Evidence-Based Decision Making 1: Critical Appraisal -- Evidence-Based Decision Making 2: Systematic Reviews and Meta-Analysis -- Evidence-Based Decision Making 3: Health Technology Assessment -- Evidence-Based Decision Making 4: Development and Limitations of Clinical Practice Guidelines -- Evidence-Based Decision-Making 5: Translational Research -- Evidence-Based Decision Making 6: Utilization of Administrative Databases for Health Services Research -- Evidence-Based Decision Making 7: Knowledge Translation -- Evidence-Based Decision Making 8: Health Policy, A Primer for Researchers.
520			_aFocusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success. Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.
700	1		_aParfrey, Patrick S _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBarrett, Brendan J _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781493924271
776	0	8	_iPrinted edition: _z9781493924295
776	0	8	_iPrinted edition: _z9781493955770
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-4939-2428-8 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2015
999			_c235754 _d235754