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001			235757
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008			100301s2001 xxu| s |||| 0|eng d
020			_a9781592591930
024	7		_a10.1385/1592591930 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aProtein Structure, Stability, and Folding _cedited by Kenneth P. Murphy.
250			_a1st edition 2001
264		1	_aTotowa, NJ _bHumana Press _c2001
300			_a1 recurso en línea (IX, 252 páginas) _b
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v168
505	0		_aStabilization of Protein Structure -- Protein Stabilization by Naturally Occurring Osmolytes -- TheThermodynamic Linkage Between Protein Structure, Stability, and Function -- Measuring the Conformational Stability of a Protein by Hydrogen Exchange -- Modeling the Native State Ensemble -- Conformational Entropy in Protein Folding -- Turn Scanning -- Laser Temperature-Jump Methods for Studying Folding Dynamics -- Kinetics of Conformational Fluctuations by EX1 Hydrogen Exchange in Native Proteins -- Molecular Dynamics Simulations of Protein Unfolding/Folding.
520			_aWith the huge increase in available data on the DNA sequences of proteins, there is a growing need to understand and characterize how proteins fold into their biologically active native states and the basis for the stability of these states. In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating aspects of protein stability and dynamics from knowledge of the structure, for calculating conformational entropy, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of this complex area by detailing many of the major innovative techniques in use today.
700	1		_aMurphy, Kenneth P _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781617371325
776	0	8	_iPrinted edition: _z9781489942081
776	0	8	_iPrinted edition: _z9780896036826
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1385/1592591930 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2001
999			_c235757 _d235757