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001			235771
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008			100301s2009 xxu| s |||| 0|eng d
020			_a9781603271929
024	7		_a10.1007/978-1-60327-192-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC
245	1	0	_aMicroarray Analysis of the Physical Genome _bMethods and Protocols _cedited by Jonathan R. Pollack.
250			_a1st edition 2009
264		1	_aTotowa, NJ _bHumana Press _c2009
300			_a1 recurso en línea (X, 224 páginas) _b36 ilustraciones
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
347			_aarchivo de texto _bPDF
490	0		_aMethods in Molecular Biology _x1940-6029 _v556
505	0		_aComparative Genomic Hybridization on BAC Arrays -- Comparative Genomic Hybridization on Spotted Oligonucleotide Microarrays -- Comparative Genomic Hybridization by Representational Oligonucleotide Microarray Analysis -- Application of Oligonucleotides Arrays for Coincident Comparative Genomic Hybridization, Ploidy Status and Loss of Heterozygosity Studies in Human Cancers -- Molecular Inversion Probe Assay for Allelic Quantitation -- A Whole-Genome Amplification Protocol for a Wide Variety of DNAs, Including Those from Formalin-Fixed and Paraffin-Embedded Tissue -- Algorithms for Calling Gains and Losses in Array CGH Data -- Methylation Analysis by Microarray -- Methylation Analysis by DNA Immunoprecipitation (MeDIP) -- Combining Chromatin Immunoprecipitation and Oligonucleotide Tiling Arrays (ChIP-Chip) for Functional Genomic Studies -- ChIP-Chip: Algorithms for Calling Binding Sites -- Mapping Regulatory Elements by DNaseI Hypersensitivity Chip (DNase-Chip) -- Microarray Analysis of DNA Replication Timing -- Integration of Diverse Microarray Data Types.
520			_aIn the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed toward the investigation of the physical genome. In Microarray Analysis of the Physical Genome: Methods and Protocols, experts in the field cover DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity (LOH), cytosine methylation, protein binding sites, regulatory elements, and replication timing, with an emphasis on higher eukaryote (animal) and cancer genomes. Written in the highly successful Methods in Molecular Biology™ series format, chapters include a brief introduction to their respective subjects, lists of the necessary materials and reagents, step-by-step protocols, and time-saving notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Microarray Analysis of the Physical Genome: Methods and Protocols is of great value to the molecular biologist or computational biologist interested in understanding the principles of these analyses or in planning future experiments using microarrays to characterize the physical genome.
700	1		_aPollack, Jonathan R _eeditor literario _4edt _4http://id.loc.gov/vocabulary/relators/edt
776	0	8	_iPrinted edition: _z9781607611264
776	0	8	_iPrinted edition: _z9781603271912
776	0	8	_iPrinted edition: _z9781617794902
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-1-60327-192-9 _z(usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
988			_aSpringer_Protocols_2009
999			_c235771 _d235771