000			05187cam a2200517Ii 4500
999			_c5836 _d5836
001			5836
003			OCoLC
005			20201203160803.0
006			m o d
007			cr cnu|||unuuu
008			160906t20162017sz o 001 0 eng d
020			_a3319351532 _q(electronic bk.)
020			_a9783319351537 _q(electronic bk.)
020			_z3319351516
020			_z9783319351513 _q(print)
035			_a(OCoLC)957772962 _z(OCoLC)957955646 _z(OCoLC)967836086
040			_aN$T _beng _erda _epn _cN$T _dIDEBK _dEBLCP _dGW5XE _dYDX _dN$T _dOCLCF _dCASUM _dOCLCA _dMERER _dOCLCO _dUAB _dOCLCO _dOCLCQ _dIOG _dESU _dZ5A _dOCLCO _dJBG _dIAD _dOCLCO _dICW _dOCLCO _dICN _dILO _dOCLCO _dOTZ _dOCLCQ _dU3W _dES-MaUEC _bspa
050		4	_aRA645.C3 _bP384 2016EB
245	0	0	_aPathology and epidemiology of cancer _cMassimo Loda, Lorelei A. Mucci, Megan L. MIttelstadt, Mieke Van Hemelrijck, Maura Bríd Cotter, editors
264		1	_aSwitzerland _bSpringer _c[2016]
264		4	_ccopyright 2017
300			_a1 recurso en línea.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
500			_aIncludes index.
500			_aSpringerLink
504			_aIncluye referencias bibliográficas e índice
505	0		_aPreface; Contents; Contributors; Part I Basic Principles of Patho-epidemiology ; 1 The Intersection of Epidemiology and Pathology; 1.1 The Intersection of Pathology and Epidemiology; 1.2 Examples from the Intersection of Epidemiology and Pathology; 1.2.1 Breast Cancer; 1.2.2 Prostate Cancer; 1.2.3 Glioblastoma; 1.2.4 Hematologic Malignancies; 1.2.5 Colorectal Cancer; 1.2.6 Genome-Wide Association Studies; 1.3 Summary; References; 2 Introduction to Histology; 2.1 Introduction to Histology; 2.2 Specimen Types; 2.3 Specimen Examination and Sampling; 2.4 Preparation of Histological Slides
505	8		_a2.4.1 Fixation of Tissue2.4.2 Processing of Tissue; 2.4.3 Sectioning of Tissue; 2.5 Staining of Tissue; 2.5.1 Immunohistochemistry; 2.5.2 In Situ Hybridization; 2.6 The Frozen Section; 2.7 Tissue Microarray Construction and Evaluation; 2.8 Microscopes, Automated Imaging, and Digital Software; 2.9 The Normal Human Cell and its Components; 2.9.1 The Cytoplasm and its Organelles; 2.9.2 The Nucleus and Gene Expression; 2.10 Basic Histology of Normal Tissues; 2.10.1 Epithelia; 2.10.2 Connective Tissues; 2.10.3 Muscles; 2.10.4 Neural Tissues; 2.11 Summary; References; 3 Introduction to Pathology
505	8		_a3.1 Introduction to Pathology3.2 Formation of Tissues and Organ Systems; 3.3 Germ Layer Derivatives; 3.3.1 Ectoderm; 3.3.2 Mesoderm; 3.3.3 Endoderm; 3.4 Cellular Adaptation and Death; 3.4.1 Atrophy; 3.4.2 Hypertrophy and Hyperplasia; 3.4.3 Metaplasia; 3.4.4 Cell Death: Necrosis and Apoptosis; 3.5 Dysplasia and Carcinoma In Situ; 3.6 Neoplasia; 3.6.1 Benign Tumors; 3.6.2 Malignant Tumors; 3.7 Important Biological Characteristics of Solid Tumors; 3.7.1 Proliferative Activity; 3.7.2 Tumor Stroma; 3.7.3 Tumor Tissue Heterogeneity; 3.7.4 Epithelial-Mesenchymal Transition; 3.8 Stage of Disease
505	8		_a3.9 SummaryReferences; 4 Basic Techniques in Molecular Pathology; 4.1 Introduction; 4.2 Material (Tissue) Selection; 4.2.1 Cell Culture; 4.2.2 Direct Human Samples; 4.2.2.1 Fluids; 4.2.2.2 Tissue; Fresh/Frozen Tissue; Formalin-Fixed Paraffin-Embedded Tissue; Other Fixatives Used in Pathology; 4.3 Nucleic Acid Purification; 4.3.1 Type of Tissue Isolation; 4.4 Analysis; 4.4.1 Focused Analytical Techniques; 4.4.1.1 Quantitative Real-Time Polymerase Chain Reaction; 4.4.1.2 Mutation-Specific PCR; 4.4.1.3 In Situ Hybridization; 4.4.2 Broad Analytical Techniques; 4.4.2.1 Microarrays; DNA Arrays
505	8		_aRNA Expression Arrays4.4.2.2 Sequencing; Sanger Sequencing; Massively Parallel Sequencing; Presequencing; Sequencing; Post-Sequencing; Uses of Massively Parallel Sequencing; Other MPS Techniques; Conclusions; 4.5 Summary; References; 5 Introduction to Cancer Epidemiology; 5.1 What Is Epidemiology?; 5.2 Measures of Disease Occurrence; 5.3 Exposure and Outcome; 5.4 Measures of Association; 5.5 Study Population; 5.6 Study Design; 5.6.1 Experimental Studies; 5.6.2 Observational Studies; 5.7 Bias and Confounding; 5.8 Summary: Epidemiological Methods as a Toolbox; References; 6 Cancer Screening
588	0		_aOnline resource; title from PDF title page (SpringerLink, viewed September 15, 2016).
988			_aEBOOK, EBSPRINGER_2017
650		7	_aCancer _xEpidemiology. _2fast _0(OCoLC)fst00845357 _9139308 _0comprobar BNE19900970859
650		7	_aCarcinogenesis. _2fast _0(OCoLC)fst00846974 _9146492 _0comprobar BNE19923478372
700	1		_aCotter, Maura Bríd, _eeditor literario
700	1		_aHemelrijck, Mieke Van, _eeditor literario
700	1		_aLoda, Massimo, _eeditor literario
700	1		_aMittelstadt, Megan L. _eeditor literario
700	1		_aMucci, Lorelei A. _eeditor literario
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-35153-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_b02/2018 _zSI _db