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020 _a9783319935218
024 7 _a10.1007/978-3-319-93521-8
_2doi
040 _bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC918
_b.D53D53 2019EB
245 0 0 _aDiabetic Nephropathy.
_bPathophysiology and Clinical Aspects
_cedited by Joris J. Roelofs, Liffert Vogt.
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2019.
300 _aXVI, 548 páginas 81 ilustraciones, 67 ilustraciones a color
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
_2rda
490 0 _aMedicine (Springer-11650)
505 0 _a1. Diabetic nephropathy – Scope of the problem -- Historical overview of diabetic kidney disease -- Clinical features and natural course of diabetic nephropathy -- Global, regional and ethnic differences in diabetic nephropathy -- Diabetic nephropathy in children and adolescents -- Renal disease in obesity, metabolic syndrome and diabesity -- 2. Pathophysiology and clinical pathology of the diabetic kidney -- Introduction to pathogenetic mechanisms of diabetic nephropathy -- The genetics of diabetic nephropathy -- Pathology of the kidney in diabetes -- 3. The glomerulus -- The mesangial cell in diabetic nephropathy -- The glomerular endothelium in diabetic nephropathy - role of heparanase -- The podocyte in diabetic nephropathy: recent advances -- Inflammatory processes in diabetic glomeruli -- 4. The tubulointerstitium -- Proteinuria and tubulotoxicity -- Tubulo-glomerular communication in diabetic nephropathy -- Mechanisms of interstitial fibrosis in diabetic nephropathy -- 5. Microvascular involvement -- Microvascular damage and hemodynamic alterations in diabetic nephropathy -- Coagulation and hemostasis in diabetic nephropathy -- Renal hemodynamics in diabetic kidney disease - relevance for intervention -- Microvascular complications in the eye: diabetic retinopathy -- 6. Macrovascular involvement -- Hypertension in diabetic kidney disease -- Macrovascular involvement in diabetes - renal artery stenosis -- Atherosclerosis and diabetic nephropathy -- 7. Experimental designs -- Animal models of diabetic kidney disease -- Clinical trial and error in diabetic nephropathy -- 8. Therapy of diabetic nephropathy -- Treatment goals in diabetic nephropathy -- Kidney transplantation and diabetic nephropathy -- 9. Future developments -- Health programs in low- and middle-income countries -- OMICs in diabetic kidney disease -- Future and novel compounds in the treatment of diabetic nephropathy.
520 3 _aThis book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed. Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.
650 1 4 _aDiabetes.
_0http://scigraph.springernature.com/things/product-market-codes/H33045
_9138582
653 0 _aDiabetes.
653 0 _aPathology.
700 1 _aRoelofs, Joris J.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aVogt, Liffert.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
_9106937
776 0 8 _iPrinted edition:
_z9783319935201
776 0 8 _iPrinted edition:
_z9783319935225
776 0 8 _iPrinted edition:
_z9783030066789
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-93521-8
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db