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020 _a9789811384332
024 7 _a10.1007/978-981-13-8433-2
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-VaUE
050 4 _aRA1270 N36
_b.V58 2019 EB
245 0 0 _aIn Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials
_cedited by Toru Takebayashi, Robert Landsiedel, Masashi Gamo.
250 _a1st ed. 2019.
264 1 _aSingapore
_bSpringer Singapore :
_bImprint: Springer
_c2019.
300 _a1 recurso en línea (VI, 223 páginas)
_b 70 ilustraciones, 62 ilustraciones a color.
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aCurrent Topics in Environmental Health and Preventive Medicine
_x2364-8333
490 0 _aMedicine (Springer-11650)
505 0 _a1 The role of in vivo screening studies in assessing manufactured nanomaterials -- Part 1 Short Term Inhalation Study -- 2. The short-term inhalation study (STIS) as a range finder and screening tool in a tiered grouping strategy -- 3. Use of short-term inhalation study to obtain initial hazard data and prepare for subacute and subchronic inhalation studies, and toxicokinetic studies -- 4. Subchronic inhalation Toxicity Study with a Vapor Grown Carbon Nanofiber in Male and Female Rats (OECD 413) - Does nanofiber exposure have adverse impacts on the cardiovascular system? -- Part 2 Intratracheal Administration Study -- 5. Comparison of responses in rat lung following inhalation and intratracheal administration of nanoparticles -- 6. Standardization of intratracheal instillation study of manufactured nanomaterials -- 7. Sample preparation and the chracterization for Intratracheal Administration -- 8. Development of intra-tracheal intra-pulmonary spraying (TIPS) as an alternative assay method for testing chronic toxicity and carcinogenic potential of multiwall carbon nanotubes -- 9. Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study using Intratracheal Administration -- 10. Toxicokinetics of nano materials after the intratracheal administration -- 11. In Vitro Alveolar Epithelial Models toward the Prediction of Cytotoxicity Tests and Translocation Studies of Nanoparticles. .
520 3 _aThis edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials. With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers.
650 7 _aMateriales nanoestructurados
_xToxicidad
_2embne
700 1 _aTakebayashi, Toru
_eeditor
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aLandsiedel, Robert
_eeditor
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aGamo, Masashi
_eeditor
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
_9106937
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789811384325
776 0 8 _iPrinted edition:
_z9789811384349
776 0 8 _iPrinted edition:
_z9789811384356
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-13-8433-2
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db
_zSI