000			04639nam a2200433 c4500
999			_c7431 _d7431
001			7431
003			ES-MaUEC
005			20200713153008.0
006			a||||fo|||| 00| 0
007			cr nn nnnanaaa
008			190619s2019 gw a o |||| 0|eng d
020			_a9783030168841
024	7		_a10.1007/978-3-030-16884-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC280 L8 _b.M47 2019 EB
245	0	0	_aMesothelioma : _bFrom Research to Clinical Practice _cedited by Giovanni Luca Ceresoli, Emilio Bombardieri, Maurizio D'Incalci.
250			_a1st ed. 2019.
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2019.
300			_a1 recurso en línea (XII, 340 páginas) _b82 ilustraciones, 56 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aMedicine (Springer-11650)
505	0		_aEpidemiology of mesothelioma -- Asbestos and pathophysiology of mesothelioma -- Screening issues in exposed subjects and early diagnosis -- Genetics and epigenetics of mesothelioma -- Microenvironment and immunology of mesothelioma -- Pre clinical models in mesothelioma -- Pathological diagnosis of mesothelioma -- Tissue and circulating biomarkers in mesothelioma -- Diagnostic imaging of mesothelioma -- Measuring malignant pleural mesothelioma -- Role of metabolic imaging in mesothelioma -- Staging of malignant pleural mesothelioma -- Surgery and multimodality treatment in malignant pleural mesothelioma -- Role of radiotherapy in malignant pleural mesothelioma -- Role of chemotherapy in malignant pleural mesothelioma -- Targeting angiogenesis in mesothelioma -- Targeted therapies in mesothelioma -- Mesothelin-targeting agents in mesothelioma -- Immunotherapy of mesothelioma: vaccines and cell therapy -- Immunotherapy of mesothelioma: immune checkpoints inhibitors -- Peritoneal mesothelioma: diagnosis and management -- Rare localizations of mesothelioma -- Unmet needs and future outlook of mesothelioma management.
520	3		_aThis book offers an updated review of malignant mesothelioma, including the latest advances in our understanding of its genetic control and molecular biology, as well as pre-clinical and clinical research. It also presents state-of-the-art diagnostic approaches and therapeutic options, and an open discussion on the future prospects for patient management. Malignant mesothelioma is an enormous global health problem related to asbestos exposure. Despite the best efforts of scientists and oncologists, the prognosis for those affected remains poor. Due to anatomical characteristics and non-specific symptoms, the diagnosis of mesothelioma at an early stage is often difficult, while surgery and radiotherapy are only of limited use, even if some multimodality approaches seem promising. In turn, medical treatments are sometimes successful in tumor control, but have little impact on overall survival. However, advances in our understanding of the disease's biology, together with the availability of new drugs and combinations, make mesothelioma an essential and highly topical field for pre-clinical and clinical studies. This book is subdivided into four parts: epidemiology and preclinical data, diagnosis, therapy, and extrathoracic mesothelioma. It highlights the progress made in a variety of areas - e.g. in vitro and in vivo experimental models, genetics, environment, biomarkers, targeting agents, immunotherapy, metabolic imaging and ongoing clinical trials - and describes the standard clinical management of mesothelioma patients, including those with extra-thoracic localizations. Given its scope, the book offers an invaluable tool for researchers, oncologists and clinicians alike.
650		7	_2embne _9670259 _aMesotelioma
700	1		_aCeresoli, Giovanni Luca _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBombardieri, Emilio _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aD'Incalci, Maurizio _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service) _9106937
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783030168834
776	0	8	_iPrinted edition: _z9783030168858
776	0	8	_iPrinted edition: _z9783030168865
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-16884-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db _zSI