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020 _a9783030050672
024 7 _a10.1007/978-3-030-05067-2
_2doi
040 _bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC261
_b.U54 2019 EB
245 1 4 _aThe Unfolded Protein Response in Cancer
_cedited by Robert Clarke.
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Humana Press
_c2019.
300 _aXI, 220 páginas 15 ilustraciones, 14 ilustraciones a color
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
_2rda
490 1 _aCancer Drug Discovery and Development,
_x2196-9906
490 0 _aMedicine (Springer-11650)
505 0 _aIntroduction: The Unfolded Protein Response -- Endoplasmic Reticulum Stress Signaling During Development -- Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy -- ATF4, Hypoxia and Treatment Resistance in Cancer -- Role of Protein Translation in the Unfolded Protein Response -- Roles of Spliced and Unspliced XBP1 in Breast Cancer -- The Unfolded Protein Response in Triple-Negative Breast Cancer -- The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer -- Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling -- Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases -- Index.
520 3 _aThis volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
650 1 4 _aCancer Research.
_0http://scigraph.springernature.com/things/product-market-codes/B11001
653 0 _aOncology.
700 1 _aClarke, Robert.
_eeditor literario
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
_9106937
776 0 8 _iPrinted edition:
_z9783030050658
776 0 8 _iPrinted edition:
_z9783030050665
830 0 _aCancer Drug Discovery and Development,
_x2196-9906
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-05067-2
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db