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020 _a9783030494766
024 7 _a10.1007/978-3-030-49476-6
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aRC280 P25
_b.T73 2020 EB
245 0 0 _aTranslational Pancreatic Cancer Research :
_bFrom Understanding of Mechanisms to Novel Clinical Trials
_cedited by Christoph W. Michalski, Jonas Rosendahl, Patrick Michl, Jörg Kleeff
250 _aFirst edition
264 1 _aCham
_bSpringer International Publishing
_c2020
300 _a1 recurso en línea (XII, 245 páginas)
_b18 ilustraciones, 17 ilustraciones a color
336 _2rdacontent
_aTexto
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _aArchivo de texto
_bPDF
490 0 _aMolecular and Translational Medicine
_x2197-7852
490 0 _aMedicine (SpringerNature-11650)
490 0 _aMedicine (R0) (SpringerNature-43714)
505 0 _aSubtypes of Pancreatic Adenocarcinoma -- Surveillance and Intervention in IPMN -- Novel Biomarkers of Invasive IPMN -- Challenges and Opportunities for Early Pancreatic Cancer Detection: Role for protein biomarkers -- Metabolic Biomarkers of Pancreatic Cancer -- Blood-Based Circulating RNAs as Preventive, Diagnostic, Prognostic and Drugable Biomarkers for Pancreatic Ductal Adenocarcinoma -- Circulating tumor DNA as a novel biomarker for pancreatic cancer -- PDAC Subtypes/Stratification -- Circulating Tumor Cells as Biomarkers in Pancreatic Cancer -- Personalized Models of Human PDAC -- Therapeutic Targeting of Stromal Components -- Epigenetic Targeting -- Targeting Metabolism -- Targeting the Immune System in Pancreatic Cancer -- Phase I Trials in Pancreatic Cancer -- Translational Approaches in Surgical Treatment.
520 _aThis book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such as those that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment. Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.
650 7 _2embne
_9194247
_aPáncreas
_xCáncer
700 1 _aMichalski, Christoph W
_eeditor
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aRosendahl, Jonas
_eeditor
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aMichl, Patrick
_eeditor
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aKleeff, Jörg
_eeditor
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink
776 0 8 _iPrinted edition:
_z9783030494759
776 0 8 _iPrinted edition:
_z9783030494773
776 0 8 _iPrinted edition:
_z9783030494780
830 0 _aMolecular and Translational Medicine,
_x2197-7852
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-49476-6
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db
_zSI