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020			_a9783030430856
024	7		_a10.1007/978-3-030-43085-6 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC267 _b.O88 2020 EB
245	0	0	_aCurrent Advances in the Science of Osteosarcoma _bResearch Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, and Canine Models _cedited by Eugenie S. Kleinerman, Richard Gorlick.
250			_aSecond edition
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2020
300			_a1 recurso en línea (I-XIII, 233 páginas) _b24 ilustraciones, 17 ilustraciones a color
336			_2rdacontent _aTexto _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_aArchivo de texto _bPDF
490	0		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v2214-8019
490	0		_aBiomedical and Life Sciences (Springer-5548)
505	0		_aFront Matter Pages i-xiii Genomic Complexity of Osteosarcoma and Its Implication for Preclinical and Clinical Targeted Therapies Courtney Schott, Avanthi Tayi Shah, E. Alejandro Sweet-Cordero Pages 1-19 Genomics and the Immune Landscape of Osteosarcoma Chia-Chin Wu, J. Andrew Livingston Pages 21-36 RECQ DNA Helicases and Osteosarcoma Linchao Lu, Weidong Jin, Lisa L. Wang Pages 37-54 Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma Christopher D. Collier, Patrick J. Getty, Edward M. Greenfield Pages 55-75 Oncolytic Viruses and Their Potential as a Therapeutic Opportunity in Osteosarcoma Mary Frances Wedekind, Timothy P. Cripe Pages 77-89 Applying Osteosarcoma Immunology to Understand Disease Progression and Assess Immunotherapeutic Response Hillary G. Pratt, E. Markel Justin, Brock A. Lindsey Pages 91-109 Targetable Intercellular Signaling Pathways Facilitate Lung Colonization in Osteosarcoma James Brandon Reinecke, Ryan David Roberts Pages 111-123 Wnt Signaling in Osteosarcoma Amit Singla, Jichuan Wang, Rui Yang, David S. Geller, David M. Loeb, Bang H. Hoang Pages 125-139 Receptor Tyrosine Kinases in Osteosarcoma: 2019 Update Edward M. Greenfield, Christopher D. Collier, Patrick J. Getty Pages 141-155 The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets Rebekah Belayneh, Kurt Weiss Pages 157-166 Autophagy in Osteosarcoma Grace Nehme, Nancy Gordon Pages 167-175 The Fas/FasL Signaling Pathway: Its Role in the Metastatic Process and as a Target for Treating Osteosarcoma Lung Metastases Nadya Koshkina, Yuanzheng Yang, Eugenie S. Kleinerman Pages 177-187 Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment Kerri Wolf-Dennen, Eugenie S. Kleinerman Pages 189-197 Comparative Immunology and Immunotherapy of Canine Osteosarcoma Nicola J. Mason Pages 199-221 Back Matter Pages 223-233
520	3		_aThis thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
650		7	_aCáncer _xInvestigación _2embne _9182523
650		7	_aFisiología celular _2embne _9165668
650		7	_aMicrobiología médica _2embne _9405049
700	1		_aKleinerman, Eugenie S _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aGorlick, Richard _eeditor _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756
776	0	8	_iPrinted edition: _z9783030430849
830		0	_aAdvances in Experimental Medicine and Biology, _x2214-8019 ; _v1258
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-43085-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
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