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008			180724s2018 gw | s |||| 0|eng d
020			_a9783030497019
024	7		_a10.1007/978-3-030-49701-9 _2doi
040			_aES-MaUEC _bspa _dES-VaUE
050		4	_aRC270 _b.M65 2020 EB
245	1	0	_aMolecular Targeted Radiosensitizers: _bOpportunities and Challenges _cedited by Henning Willers, Iris Eke
264		1	_aCham _bSpringer International Publishing : _bImprint: Springer _c2020.
300			_a1 recurso en línea (I-XI, 364 páginas) _bilustraciones a color
336			_2rdacontent _aTexto (visual) _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aMedicine (Springer-11650)
505	0		_aIntroduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges Henning Willers, Iris Eke Pages 1-16 Translating Targeted Radiosensitizers into the Clinic Deborah E. Citrin, Kevin A. Camphausen Pages 17-33 Mapping the Radiogenome of Human Cancers Priyanka Gopal, Jessica A. Castrillon, Mohamed E. Abazeed Pages 35-61 Mechanisms and Markers of Clinical Radioresistance Michael S. Binkley, Maximilian Diehn, Iris Eke, Henning Willers Pages 63-96 Preclinical Strategies for Testing of Targeted Radiosensitizers Steven H. Lin, Rui Ye, Yifan Wang Pages 97-114 3D Radiation Biology for Identifying Radiosensitizers Anne Vehlow, Sara Sofia Deville, Nils Cordes Pages 115-135 Preclinical In Vivo Evaluation of Novel Radiosensitizers by Local Tumor Control Experiments Karolin Schneider, Nadja Ebert, Ina Kurth, Michael Baumann Pages 137-159 Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers Warren Floyd, Hsuan-Cheng Kuo, Jonathon E. Himes, Rutulkumar Patel, David G. Kirsch Pages 161-190 Targeting the DNA Damage Response for Radiosensitization Matthew T. McMillan, Theodore S. Lawrence, Meredith A. Morgan Pages 191-218 Targeting Tumor Metabolism to Overcome Radioresistance Daniel Wahl, Michael Petronek, Rashmi Ramachandran, John Floberg, Bryan G. Allen, Julie K. Schwarz Pages 219-263 Targeting Tumor Hypoxia Michael Skwarski, Elizabeth Bowler, Joseph D. Wilson, Geoff S. Higgins, Ester M. Hammond Pages 265-299 Normalizing the Tumor Microenvironment for Radiosensitization John D. Martin, Rakesh K. Jain Pages 301-338 Radiosensitizers in the Era of Immuno-Oncology Jonathan E. Leeman, Jonathan D. Schoenfeld Pages 339-360
520	3		_aMolecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
988			_aEBSPRINGER_2020
650		0	_aBiomedical _9513764
700			_aWillers, Henning _9515919
700			_aEke, Iris _9515920
710			_aSpringerLink _0http://id.loc.gov/authorities/names/no2005046756 _0http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9783030497002
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-49701-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db _feng _ggw _h0