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020 _a9783030521233
024 7 _a10.1007/978-3-030-52123-3
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-VaUE
050 4 _aQR92
_b.B33 2020 EB
245 1 0 _aBacterial Type III Protein Secretion Systems
_cedited by Samuel Wagner, Jorge E. Galan
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2020
300 _a1 recurso en línea (I-VII, 230 páginas)
_bilustraciones a color
336 _aTexto
_btxt
_2rdacontent
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aBiomedical and Life Sciences (Springer-11642)
505 0 _aA Unified Nomenclature for Injectisome-Type Type III Secretion Systems Samuel Wagner, Andreas Diepold Pages 1-10 Transcriptional and Post-transcriptional Regulatory Mechanisms Controlling Type III Secretion Marcel Volk, Ines Vollmer, Ann Kathrin Heroven, Petra Dersch Pages 11-33 Assembly and Post-assembly Turnover and Dynamics in the Type III Secretion System Andreas Diepold Pages 35-66 The Structure of the Type III Secretion System Needle Complex Sean Miletic, Nikolaus Goessweiner-Mohr, Thomas C. Marlovits Pages 67-90 Molecular Organization and Assembly of the Export Apparatus of Flagellar Type III Secretion Systems Tohru Minamino, Akihiro Kawamoto, Miki Kinoshita, Keiichi Namba Pages 91-107 Structures of Type III Secretion System Needle Filaments Birgit Habenstein, Nadia El Mammeri, James Tolchard, Gaëlle Lamon, Arpita Tawani, Mélanie Berbon et al. Pages 109-131 The Type III Secretion System Sorting Platform María Lara-Tejero Pages 133-142 Export Mechanisms and Energy Transduction in Type-III Secretion Machines Thibaud T. Renault, Alina Guse, Marc Erhardt Pages 143-159 Flagellar Hook/Needle Length Control and Secretion Control in Type III Secretion Systems Shin-Ichi Aizawa Pages 161-172 The Tip Complex: From Host Cell Sensing to Translocon Formation William D. Picking, Michael L. Barta Pages 173-199 Diversity and Evolution of Type III Secreted Effectors: A Case Study of Three Families Donald Patrick Bastedo, Timothy Lo, Bradley Laflamme, Darrell Desveaux, David S. Guttman Pages 201-230
520 3 _aOne of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into eukaryotic and prokaryotic target cells to modulate a variety of cellular functions for the pathogen’s benefit. These protein-delivery machines include the type III secretion system (T3SS), which is widespread in nature and encoded not only by bacteria pathogenic to vertebrates or plants, but also by bacteria that are symbiotic to plants or insects. Because they are essential virulence factors for many important human pathogens, these systems are emerging as a prime target for the development of new-generation, anti-infective drugs. This book reviews our current understanding of these intriguing injection machines as well as of the closely related T3SS that serves in flagella assembly. Individual chapters focus on regulation, assembly, structure, and function of the type III secretion machine and on the evolution of the secreted effector proteins. Given its scope, this book will appeal to a broad readership, including researchers and teachers in the fields of infectious diseases, host pathogen interactions, plant and animal pathogenesis, and symbiosis.
650 7 _aMicrobiología médica
_9273339
_2embne
650 7 _aEnfermedades infecciosas
_96694
_2embne
700 _aWagner, Samuel
_9516042
700 _aGalan, Jorge E.
_9516043
710 _aSpringerLink
_0http://id.loc.gov/authorities/names/no2005046756
_9106996
776 0 8 _iEdición impresa:
_z9783030521226
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-52123-3
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db
_feng
_ggw
_h0