| 000 | 07908cam a2200433Mi 4500 | ||
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| 999 |
_c8643 _d8643 |
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| 001 | 8643 | ||
| 003 | OCoLC | ||
| 005 | 20201017193121.0 | ||
| 006 | m o d | ||
| 007 | cr nn||||mamaa | ||
| 008 | 170601s2017 gw a ob 001 0 eng d | ||
| 020 | _z9783030491277 | ||
| 024 |
_2doi _a10.1007/978-3-030-49127-7 |
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_a(OCoLC)996406765 _z(OCoLC)988941421 _z(OCoLC)989050024 _z(OCoLC)989549268 _z(OCoLC)994128541 _z(OCoLC)994467521 _z(OCoLC)1003522992 _z(OCoLC)1004391397 |
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| 050 | 4 |
_aQR188.8 _b.C55 2020 EB |
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| 245 | 0 | 0 |
_aClinical Xenotransplantation: _bPathways and Progress in the Transplantation of Organs and Tissues Between Species _cedited by David K. C. Cooper, Guerard Byrne |
| 260 | _a1st ed. 2020 | ||
| 264 | 1 |
_aCham _bSpringer International Publishing : _bImprint : _bSpringer _c2020 |
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| 300 |
_a1 recurso en línea (I-XXIX , 572 páginas) _bilustraciones a color |
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| 336 |
_aTexto (visual) _btxt _2rdacontent |
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| 337 |
_aelectrónico _bc _2rdamedia |
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| 338 |
_arecurso electrónico _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | _aMedicine (Springer - 11650) | ||
| 500 | _aSpringerLink | ||
| 505 | 0 | _aClinical and Experimental Xenotransplantation: Background Front Matter Pages 1-1 A Brief History of Clinical Cross-Species Organ Xenotransplantation David K. C. Cooper Pages 3-26 The Pathobiology of Pig-to-Primate Xeno.: A Historical Review David K. C. Cooper, Mohamed B. Ezzelarab, Hidetaka Hara, Hayato Iwase, Whayoung Lee, Martin Wijkstrom et al. Pages 27-63 Is Sensitization to Pig Antigens Detrimental to Subsequent Allotransplantation? Qi Li, Hidetaka Hara, Zhongqiang Zhang, Michael E. Breimer, Yi Wang, David K. C. Cooper Pages 65-78 Sensitization to Human Leukocyte Antigens and Xenotransplantation Guerard Byrne Pages 79-87 Pig Kidney and Heart Xenotransplantation in Nonhuman Primates: The Present Position Front Matter Pages 89-89 Kidney Xenotransplantation in Nonhuman Primates David K. C. Cooper, Hidetaka Hara, Hayato Iwase, Takayuki Yamamoto, Abhijit Jagdale, Douglas J. Anderson et al. Pages 91-106 Cardiac Xenotransplantation in Nonhuman Primates David K. C. Cooper Pages 107-117 Organ-Source Pig Genetic Engineering and Regulation Front Matter Pages 119-119 Gene-edited Pigs for Xenotransplantation Willard Eyestone, Kent Adams, Suyapa Ball, John Bianchi, Steve Butler, Amy Dandro et al. Pages 121-140 Addressing Regulatory Requirements for the Organ-Source Pig – A Pragmatic Approach to Facility Design and Pathogen Prevention Karl Kraebber, Edward Gray Pages 141-153 Antibody-Mediated Allotransplant Rejection: Lessons for Xenotransplantation Front Matter Pages 155-155 Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection Stuart J. Knechtle, Jean Kwun, Brendon Lovasik, Alton B. Farris, A. Joseph Tector, Andrew B. Adams Pages 157-164 Management of Anti-HLA Antibodies and Acute Antibody-Mediated Rejection Robert A. Montgomery Pages 165-175 Evolving Approaches to Treatment of Allosensitization and Antibody-Mediated Rejection Stanley C. Jordan, Noriko Ammerman, Ashley Vo Pages 177-189 Lessons from ABO-Incompatible Cardiac Allotransplantation in the Newborn Jeffrey L. Platt, Marilia Cascalho Pages 191-201 Patient Evaluation and Selection for First Clinical Trials of Kidney or Heart Xenotransplantation Front Matter Pages 203-203 Defining an “Acceptable Risk Threshold”: Who Should Be the First Kidney Xenotransplant Recipient? Jayme E. Locke Pages 205-207 Selection of Patients for the Initial Clinical Trials of Kidney Xenotransplantation David K. C. Cooper, Abhijit Jagdale, Roslynn B. Mannon, Vineeta Kumar, Robert Gaston, Michael J. Hanaway et al. Pages 209-220 Selection of Patients for the Initial Clinical Trials of Cardiac Xenotransplantation Richard N. Pierson III, Lars Burdorf, David A. D’Alessandro Pages 221-232 Selection of Pediatric Patients for the Initial Clinical Trials of Cardiac Xenotransplantation James K. Kirklin, David C. Cleveland Pages 233-242 Infection in Xenotransplantation: Organ-Source Health and Patient Safety Jay A. Fishman Pages 243-252 Histocompatibility Testing for Xenotransplantation Joseph M. Ladowski, Gregory R. Martens Pages 253-263 Regulatory, Economic, and Social Aspects of Clinical Trials of Xenotransplantation Front Matter Pages 265-265 Xenotransplantation: The FDA Perspective Winson W. Tang, Judith Arcidiacono Pages 267-271 Xenotransplantation: A Payer’s Perspective Jon Friedman Pages 273-276 Public Perceptions Toward the Clinical Trials of Organ Xenotransplantation Wayne Paris, Chace Mitchell, Zoie Werkheiser, Alan Lipps, David K. C. Cooper, Luz A. Padilla Pages 277-285 Summation Front Matter Pages 287-287 What Did the Workshop Achieve? Devin E. Eckhoff, Guerard Byrne Pages 289-297 | |
| 520 | 3 | _aThis title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation. | |
| 650 | 7 |
_9138557 _aCardiología _2fast _0(OCoLC)fst00847121 _0Local |
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| 650 | 7 |
_aChest _xSurgery. _2fast _0(OCoLC)fst00853847 _9549169 _0Local |
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| 650 | 7 |
_aCorazón _xCirugía _2embne _0(OCoLC)fst00953666 _0Local _9174357 |
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| 650 | 7 |
_aTransplantation of organs, tissues, etc. _2fast _0(OCoLC)fst01154919 _9548257 _0Local |
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| 650 | 7 |
_9405021 _aMedicina _2fast _0(OCoLC)fst01014893 _0Local |
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| 700 |
_aCooper, David K. C. _9516290 |
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| 700 |
_aByrne, Guerard _9516291 |
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| 856 | 4 | 0 |
_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-030-49127-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia) |
| 942 |
_2lcc _cLE |
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| 998 |
_b02/2018 _db _zSI |
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