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020 _a9783030538682
024 7 _a10.1007/978-3-030-53868-2
_2doi
040 _aES-MaUEC
_bspa
_dES-VaUE
050 4 _aQR181
_b.G68 2020 EB
100 1 _aLand, Walter Gottlieb.
_eautor
_0(orcid)0000-0002-0090-0629
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
245 1 0 _aDamage-Associated Molecular Patterns in Human Diseases:
_bVolume 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets
_cby Walter Gottlieb Land
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2020
300 _a1 recurso en línea ( I-XXXIX, 629 páginas)
_bIlustraciones a color
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aMedicine (Springer-11650)
505 0 _aPrologue Front Matter Pages 1-1 Perspectives of the Danger/Injury Model in Immunology Walter Gottlieb Land Pages 3-9 A Select, Clinically Oriented Update of Topics Presented in “Damage-Associated Molecular Patterns in Human Diseases”; Volume 1: Injury-Induced Innate Immune Responses Front Matter Pages 11-11 Pattern Recognition Molecules Walter Gottlieb Land Pages 13-65 The Growing World of DAMPs Walter Gottlieb Land Pages 67-116 The Growing Clinical Relevance of Cellular Stress Responses and Regulated Cell Death Walter Gottlieb Land Pages 117-150 DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation Walter Gottlieb Land Pages 151-209 DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Fibrosis Walter Gottlieb Land Pages 211-257 DAMPs and SAMPs in Traumatic Disorders, Atherosclerosis, and Cerebro-Cardiovascular Diseases Front Matter Pages 259-259 DAMPs and SAMPs as Molecular Biomarkers, Therapeutic Targets, and Therapeutics Walter Gottlieb Land Pages 261-278 DAMP-Controlled and Uncontrolled Responses to Trauma: Wound Healing and Polytrauma Walter Gottlieb Land Pages 279-335 Solid Organ Injury Walter Gottlieb Land Pages 337-430 Atherosclerosis Walter Gottlieb Land Pages 431-533 Cerebro-Cardiovascular Diseases Walter Gottlieb Land Pages 535-623 Epilogue Front Matter Pages 625-625 The “DAMPome” as a Key Player in the Pathogenesis of Human Diseases Walter Gottlieb Land Pages 627-629
520 3 _aThis book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs (“SAMPs”) is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses
650 7 _aImmunología
_2embne
_9547906
650 0 _aMedicine
_9512161
650 0 _aPublic health
_9512171
650 0 _aInternal medicine
_9512942
710 _aSpringerLink
_0http://id.loc.gov/authorities/names/no2005046756
_0http://viaf.org/viaf/148105729
_9106996
776 0 8 _iEdición impresa:
_z9783030538675
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-53868-2
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
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