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008			170918s2018 si | s |||| 0|eng d
020			_a9789811053368
024	7		_a10.1007/978-981-10-5336-8 _2doi
040			_aES-MaUEC _bspa _dES-VaUE
050		4	_aRM267 _b.A585 2018 EB
090		4	_aRM121
245	1	0	_aAntibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill _cedited by Andrew A. Udy, Jason A. Roberts, Jeffrey Lipman.
264		1	_aSingapore _bSpringer Singapore : _bImprint: Adis _c2018.
300			_a1 recurso en línea (X, 275 páginas 22 ilustraciones, 9 ilustraciones a color)
336			_2rdacontent _aTexto (visual) _btxt
337			_2rdamedia _aelectrónico _bc
338			_2rdacarrier _arecurso electrónico _bcr
347			_atext file _bPDF
490	0		_aMedicine (Springer-11650)
505	0		_a1. Basic Pharmacokinetic Principles -- 2. Antibiotic Pharmacodynamics -- 3. Physiological Manifestations of Critical Illness -- 4. Dosing in Obese Critically Ill Patients -- 5. Hypoalbuminemia and Altered Protein Binding -- 6. Antibacterial Pharmacokinetic/Pharmacodynamic Considerations in the Critically ill -- 7. Augmented Renal Clearance -- 8. Antibiotic Dosing During Extracorporeal Membrane Oxygenation -- 9. Therapeutic Drug Monitoring: More than Avoiding Toxicity -- 10. Generic and Optimised Antibacterial Dosing Strategies in the Critically Ill -- 11. Antifungal PK/PD in the Critically Ill -- 12. Antibiotic Dosing in Pediatric Critically Ill Patients -- 13. Antibiotic Stewardship in the Intensive Care Unit.
520	3		_aThis book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU.  Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.
653		0	_aPharmaceutical technology.
653	1	4	_aPharmacotherapy.
653	2	4	_aPharmaceutical Sciences/Technology.
700	1		_aUdy, Andrew A. _eeditor literario _0http://id.loc.gov/authorities/names/n2018183998 _0http://viaf.org/viaf/97152380158401762750
700	1		_aRoberts, Jason A. _eeditor literario _0http://viaf.org/viaf/1270147665806660670000 _999955
700	1		_aLipman, Jeffrey. _eeditor literario _0http://id.loc.gov/authorities/names/n2011187094 _0http://viaf.org/viaf/227422453
710	2		_aSpringerLink (Online service) _0http://id.loc.gov/authorities/names/no2005046756 _0http://viaf.org/viaf/148105729 _9106996
776	0	8	_iEdición impresa: _z9789811053351
776	0	8	_iEdición impresa: _z9789811053375
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-10-5336-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db