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020			_a9783030531683 ( _q) ( _qelectronic bk.)
020			_a3030531686 ( _q) ( _qelectronic bk.)
020			_z3030531678
020			_z9783030531676
024	7		_a10.1007/978-3-030-53168-3 _2doi
024	1		_aAU@ _b000068176391
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245	0	0	_aPET and SPECT in neurology _cRudi A. J. O. Dierckx, Andreas Otte, Erik F. J. de Vries, Aren van Waarde, editors ; Klaus L. Leenders, guest editor
250			_a2nd ed
260			_aCham _bSpringer _c2021
300			_a1 online resource (1270 p.)
336			_atext _btxt [ _2rdacontent]
337			_acomputer _bc [ _2rdamedia]
338			_aonline resource _bcr [ _2rdacarrier]
500			_aDescription based upon print version of record
505	0		_aIntro -- Foreword -- Preface -- Contents -- Part I: Basics -- 1: Nuclear Medicine Imaging Tracers for Neurology -- 1.1 Introduction -- 1.2 Glucose Consumption -- 1.3 Translocator Protein TSPO -- 1.4 GABA Receptor -- 1.5 Dopaminergic System -- 1.5.1 Dopamine Transporter (DAT) -- 1.5.2 D1 Receptor -- 1.5.3 D2 Receptor -- 1.5.4 D2/D3 Agonists -- 1.6 Beta-Amyloid Deposition -- 1.7 NMDA Receptor, Glycine Transport -- 1.8 P-Glycoprotein -- 1.9 Cholinergic System -- 1.10 Metabotropic Glutamate-5 Receptor -- 1.11 Vesicular Monoamine Transporter -- 1.12 Adenosine Receptors
505	8		_a1.13 Serotonergic System -- 1.13.1 Serotonin Transporter -- 1.13.2 5-HT Receptor Ligands -- 1.14 Nonadrenergic System -- 1.15 Opioid Receptors -- 1.16 Monoamine Oxidase -- 1.17 SV2A Receptors -- 1.18 Sigma Receptors -- 1.19 Tau Protein Deposition -- 1.20 Phosphodiesterase -- 1.21 P2X7 Receptor -- 1.22 (Re)Myelination -- 1.23 Cannabinoid Receptors -- 1.24 Conclusions -- References -- 2: Tracer Kinetic Modelling -- 2.1 Introduction -- 2.2 Principles of Modelling -- 2.3 Single-Tissue Compartment Model -- 2.4 Principles and Practice of Quantification
505	8		_a2.5 An Example: Measurement of CBF Using [15O]H2O -- 2.6 Two-Tissue Compartment Model -- 2.7 Reference Tissue Models -- 2.8 Parametric Methods -- 2.9 Conclusions -- References -- 3: Quantification in Brain SPECT: Noninvasive Cerebral Blood Flow Measurements Using 99mTc-Labeled Tracers -- 3.1 Introduction -- 3.2 Method -- 3.2.1 Theory of Graphical Analysis -- 3.2.2 Brain Perfusion Index (BPI) -- 3.2.3 Comparison of BPI and CBF Values Measured by Other Invasive Methods -- 3.2.4 Alternative Approach to Estimation of BPI -- 3.2.5 Calculation of Regional CBF from BPI
505	8		_a3.2.6 Consecutive rCBF Measurements at Baseline and Acetazolamide Challenge -- 3.3 Clinical Application -- 3.3.1 Cerebrovascular Diseases -- 3.3.2 Heart Failure -- 3.3.3 Idiopathic Normal Pressure Hydrocephalus -- 3.3.4 Neurodegenerative Disorders -- 3.3.5 Mood Disorders -- 3.3.6 Other Neuropsychiatric Diseases -- 3.4 Conclusion -- References -- 4: From Positron to Pattern: A Conceptual and Practical Overview of 18F-FDG PET Imaging and Spatial Covariance Analysis -- 4.1 18F-FDG PET Imaging -- 4.1.1 Basic Concepts in PET -- 4.1.2 18F-FDG PET Imaging
505	8		_a4.1.3 Studying Brain Function with 18F-FDG PET -- 4.2 Analysis of Resting-State 18F-FDG PET Images -- 4.2.1 Image Registration -- 4.2.2 Normalization -- 4.2.3 Analysis of Variance and Covariance -- 4.2.4 Principal Component Analysis -- 4.3 SSM PCA -- 4.3.1 Defining the Data -- 4.3.2 Normalization with the Scaled Subprofile Model (SSM) -- 4.3.3 Calculating Eigenvectors from a Covariance Matrix -- 4.3.4 Calculating Subject Scores and Selecting Disease-Related Components -- 4.3.5 Prospective Application of the Pattern -- 4.3.6 Validation
520			_aThis book provides a comprehensive overview of the use of PET and SPECT in not only classic neurodegenerative disorders but also cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The new edition has been revised and updated to reflect recent advances and includes additional chapters, for example on the use of artificial intelligence and machine learning in imaging data analysis, the study of brain connectivity using PET and SPECT images, and the role of PET imaging in modulation of brain functioning by deep brain stimulation. The authors are renowned experts whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state of the art compendium will be invaluable for neurologists and radiologists/nuclear medicine specialists and will also be informative for interested general practitioners and geriatricians. Companion volumes on PET and SPECT in psychiatry and in neurobiological systems complete a trilogy
650		0	_aNervous system- _xDiseases- _xTomography
650		0	_aTomography, Emission
650		7	_aNeurology.
650		7	_aNuclear medicine.
650		7	_aRadiology.
655		4	_aElectronic books
700	1		_aDierckx, Rudi A. J. O.
700	1		_aOtte, Andreas P. ( _d1967-)
700	1		_aVries, Erik F. J. de
700	1		_aWaarde, Aren van
700	1		_aLeenders, Klaus L.
776	0	8	_iPrint version _aDierckx, Rudi A. J. O _tPET and SPECT in Neurology _dCham : Springer International Publishing AG,c2020 _z9783030531676
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-030-53168-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942			_2lcc _cLE
998			_db