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020 _a9783319605111
024 7 _a10.1007/978-3-319-60511-1
_2doi
040 _aES-MaUEC
_bspa
_dES-VaUE
050 4 _aRC269
_b.T866 2018 EB
245 1 0 _aTumor Organoids
_cedited by Shay Soker, Aleksander Skardal.
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Humana Press
_c2018.
300 _a1 recurso en línea (XVI, 213 páginas 52 ilustraciones, 50 ilustraciones a color)
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aCancer Drug Discovery and Development
_x2196-9906
490 0 _aMedicine (Springer-11650)
505 0 _aTechniques to Produce and Culture Lung Tumor Organoids -- Tissue Organoids: Liver -- Mammary Gland Organoids -- Biofabrication Technologies for Developing In Vitro Tumor Models -- Three Dimensional In Vitro Tumor Platforms for Cancer Discovery -- Tissue-engineered models for studies of bone metastasis -- Building Better Tumor Models: Organoid Systems to Investigate Angiogenesis -- Microfluidics in cell and tissue studies -- Stiffness-tuned matrices for tumor cell studies -- Mathematical modeling of tumor organoids: toward personalized medicine.
520 3 _aCancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
650 7 _aOncología
_9139207
_2embne
650 7 _aCélulas cancerosas
_9146156
_2embne
700 1 _aSoker, Shay.
_eeditor literario
_0http://id.loc.gov/authorities/names/n2018183108
_0http://viaf.org/viaf/308796813
700 1 _aSkardal, Aleksander.
_eeditor literario
_0http://id.loc.gov/authorities/names/n2018183109
_0http://viaf.org/viaf/40152501092710681291
710 2 _aSpringerLink (Online service)
_0http://id.loc.gov/authorities/names/no2005046756
_0http://viaf.org/viaf/148105729
_9106996
776 0 8 _iEdición impresa:
_z9783319605098
776 0 8 _iEdición impresa:
_z9783319605104
776 0 8 _iEdición impresa:
_z9783319868745
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-60511-1
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db