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020 _a9783319644516
024 7 _a10.1007/978-3-319-64451-6
_2doi
040 _aES-MaUEC
_bspa
_dES-VaUE
050 4 _aRC268.5
_b.D797 2018 EB
245 1 0 _aD-type Cyclins and Cancer
_cedited by Philip W. Hinds, Nelson E. Brown.
264 1 _aCham
_bSpringer International Publishing :
_bImprint: Springer
_c2018.
300 _a1 recurso en línea (IX, 152 páginas 29 ilustraciones, 25 ilustraciones a color)
336 _2rdacontent
_aTexto (visual)
_btxt
337 _2rdamedia
_aelectrónico
_bc
338 _2rdacarrier
_arecurso electrónico
_bcr
347 _atext file
_bPDF
490 0 _aCurrent Cancer Research
_x2199-2584
490 0 _aMedicine (Springer-11650)
505 0 _aThe D-type Cyclins: A Historical Perspective -- Mammalian Development and Cancer – A Brief History of Mice Lacking D-type Cyclins or Cdk4/6 -- D-type Cyclins and Gene Transcription -- Splice Variants and Phosphorylated Isoforms of Cyclin D1 in Tumorigenesis -- Cyclin D1, Metabolism, and the Autophagy-Senescence Balance -- Shifting a Paradigm: Cyclin D Activates pRb by Mono-Phosphorylation.
520 3 _aThis volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.
650 7 _aOncología
_9139207
_2embne
650 7 _aCarcinogénesis
_2embne
_9146492
700 1 _aHinds, Philip W.
_eeditor literario
_0http://id.loc.gov/authorities/names/nr89009656
_0http://viaf.org/viaf/56749876
700 1 _aBrown, Nelson E.
_eeditor literario
_0http://id.loc.gov/authorities/names/no2009120839
_0http://viaf.org/viaf/96820149
710 2 _aSpringerLink (Online service)
_0http://id.loc.gov/authorities/names/no2005046756
_0http://viaf.org/viaf/148105729
_9106996
776 0 8 _iEdición impresa:
_z9783319644493
776 0 8 _iEdición impresa:
_z9783319644509
776 0 8 _iEdición impresa:
_z9783319877976
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-319-64451-6
_zAcceso a este recurso digital (usuarios Universidad Europea de Valencia)
942 _2lcc
_cLE
998 _db